Roles of PCT,HNL and CD64 in the diagnosis of bacterial infection

doi:10.3969/j.issn.1673-8640.2019.05.010

Abstract

Abstract:

Objective To investigate the roles of procalcitonin （PCT）,human neutrophil lipocalin （HNL）and neutrophil CD64 in the diagnosis of bacterial infection. Methods A total of 86 patients with suspected bacterial infection were enrolled. There were 44 cases of bacterial infection group,42 cases of viral infection group and 40 cases of healthy subjects（healthy control group）. The levels of PCT,HNL,CD64 and white blood cell （WBC） count of bacterial infection,viral infection and healthy control groups were determined,and the diagnostic roles of PCT,HNL and CD64 were evaluated by receiver operating characteristic（ROC）curve. Results Compared with viral infection and healthy control groups,PCT,HNL and CD64 levels and WBC counts in bacterial infection group were increased（P<0.05）. CD64 level and WBC count were increased in viral infection group compared with healthy control group（P<0.05）. The sensitivities of PCT,HNL,CD64 and WBC count for the diagnosis of bacterial infection were 79.55%,84.09%,81.82% and 77.27%,respectively. The specificities were 83.33%,88.09%,85.71% and 85.71%,respectively. The areas under ROC curves （AUC） of HNL,CD64,PCT and WBC count were 0.914,0.900,0.837 and 0.748,respectively. Conclusions HNL,CD64,PCT and WBC count can be used in the diagnosis of bacterial infection. HNL plays a role for the diagnosis of bacterial infection.

Key words: Procalcitonin, Human neutrophil lipocalin, Neutrophil CD64, Bacterial infection

CLC Number:

R446.1

MA Caiyan, LAI Wenqiang, CHEN Xiaoping. Roles of PCT,HNL and CD64 in the diagnosis of bacterial infection[J]. Laboratory Medicine, 2019, 34(5): 433-436.

Figures/Tables 3

References 13

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组别	例数	PCT（ng/mL）	HNL（μg/L）	CD64（%）	WBC（×10⁹/L）
病毒感染组	42	0.32±0.14	50.68±8.16	10.58±3.52^*	10.61±3.21^*
细菌感染组	44	2.16±0.87^*#	162.71±16.97^*#	15.23±3.28^*#	14.62±3.24^*#
正常对照组	40	0.24±0.12	41.27±7.81	5.87±1.81	7.64±2.12
F值		17.475	21.382	14.682	11.173
P值		0.011	0.000	0.024	0.037

组别	例数	PCT（ng/mL）	HNL（μg/L）	CD64（%）	WBC（×10⁹/L）
病毒感染组	42	0.32±0.14	50.68±8.16	10.58±3.52^*	10.61±3.21^*
细菌感染组	44	2.16±0.87^*#	162.71±16.97^*#	15.23±3.28^*#	14.62±3.24^*#
正常对照组	40	0.24±0.12	41.27±7.81	5.87±1.81	7.64±2.12
F值		17.475	21.382	14.682	11.173
P值		0.011	0.000	0.024	0.037

指标	AUC （95%可信区间）	最佳临界值	敏感性（%）	特异性（%）	阳性预测值（%）	阴性预测值（%）
PCT	0.837（0.811~0.897）	1.89 ng/mL	79.55	88.09	85.70	80.43
HNL	0.914（0.864~0.913）	142.37 μg/L	84.09	88.09	88.09	84.09
CD64	0.900（0.844~0.953）	13.15 %	81.82	90.48	90.00	82.60
WBC计数	0.748（0.714~0.811）	12.80 ×10⁹/L	77.27	90.48	89.47	79.17

指标	AUC （95%可信区间）	最佳临界值	敏感性（%）	特异性（%）	阳性预测值（%）	阴性预测值（%）
PCT	0.837（0.811~0.897）	1.89 ng/mL	79.55	88.09	85.70	80.43
HNL	0.914（0.864~0.913）	142.37 μg/L	84.09	88.09	88.09	84.09
CD64	0.900（0.844~0.953）	13.15 %	81.82	90.48	90.00	82.60
WBC计数	0.748（0.714~0.811）	12.80 ×10⁹/L	77.27	90.48	89.47	79.17

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