Serum homocysteine level in patients with recurrent spontaneous abortion

doi:10.3969/j.issn.1673-8640.2017.06.008

Abstract

Abstract:

Objective To investigate the relationship between serum homocysteine （Hcy） level and recurrent spontaneous abortion （RSA）,and to analyze the causes for hyperhomocysteinemia. Methods A total of 197 non-pregnant patients with RSA for ≥2 times were enrolled,and they were classified into non-pathologic disease group （146 cases）and pathologic disease group （51 cases）according to the results of B ultrasound and related determinations. A total of 83 healthy pregnant women were enrolled as pregnant group,and 60 healthy non-pregnant women were enrolled as healthy control group. Serum levels of Hcy,folic acid （FA） and vitamin B₁₂ （Vit B₁₂） in RSA group were determined,and pregnant and healthy control groups were determined only for serum Hcy level. Results Serum Hcy level in RSA group was higher than those in pregnant group （P<0.001）and healthy control group （P<0.05）. There was no statistical significance for serum Hcy level in RSA group with and without pathologic diseases （P>0.05）. Serum Hcy level was lower in ≥30-year-old RSA group than that in <30-year-old RSA group （P=0.03）. Serum Hcy levels in ≥30-year-old and <30-year-old RSA groups were higher than that in age-matched pregnant group（P<0.001）. Serum Hcy level was higher in <30-year-old RSA group than that in age-matched healthy control group （P<0.05）,whereas there was no statistical significance between the 2 groups aged ≥30-year-old （P>0.05）. In non-pathologic disease group,there were 9.59% patients with increasing Hcy level,14.38% with decreasing FA level and 4.11% with decreasing Vit B₁₂ level. The incidence rate of low FA level was higher in group with high Hcy level than that with normal Hcy level （P<0.001）. There was negative correlation of Hcy with FA and Vit B₁₂ （r=-0.599 and -0.503,P<0.05）. No statistical significance was observed in serum Hcy,FA and Vit B₁₂ levels among RSA patients with different times of abortion（2,3 and ≥4 times）（P>0.05）. Conclusions RSA might be correlated with hyperhomocysteinemia,which may be caused by the deficiency of FA.

Key words: Homocysteine, Folic acid, Vitamin B12, Recurrent spontaneous abortion

CLC Number:

R446.1

LIU Yuan, SUN Wenqin, LU Wenhui, ZHANG Jun, CHEN Huifen. Serum homocysteine level in patients with recurrent spontaneous abortion[J]. Laboratory Medicine, 2017, 32(6): 481-485.

Figures/Tables 4

References 19

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组别	例数	Hcy
RSA组	197
无病理异常	146	7.60（6.30~9.30）^*#
有病理异常	51	8.30（6.70~11.65）^**#
凝血功能异常	14	7.60（6.20~10.30）^**#
内分泌功能异常	18	8.50（7.30~17.90）^**#
免疫功能异常	19	8.40（6.60~10.78）^**#
正常对照组	60	7.20（6.55~7.80）^#
妊娠组	83	4.80（3.90~5.85）

组别	例数	Hcy
RSA组	197
无病理异常	146	7.60（6.30~9.30）^*#
有病理异常	51	8.30（6.70~11.65）^**#
凝血功能异常	14	7.60（6.20~10.30）^**#
内分泌功能异常	18	8.50（7.30~17.90）^**#
免疫功能异常	19	8.40（6.60~10.78）^**#
正常对照组	60	7.20（6.55~7.80）^#
妊娠组	83	4.80（3.90~5.85）

组别	例数	Hcy
组别	例数	<30岁	≥30岁
RSA组	197	8.30（6.50~11.18）	7.50（6.30~9.20）
正常对照组	60	7.10（6.20~7.50）^*#	7.40（6.63~7.90）
妊娠组	83	4.80（3.90~5.53）^**#	4.70（3.80~6.40）^**#

组别	例数	Hcy
组别	例数	<30岁	≥30岁
RSA组	197	8.30（6.50~11.18）	7.50（6.30~9.20）
正常对照组	60	7.10（6.20~7.50）^*#	7.40（6.63~7.90）
妊娠组	83	4.80（3.90~5.53）^**#	4.70（3.80~6.40）^**#

组别	例数	FA		Vit B₁₂
组别	例数	降低	正常	降低	正常
高Hcy组	14	11（78.57）	3（21.43）	2（14.29）	12（85.71）
Hcy正常组	132	10（7.58）	122（92.42）	4（3.03）	128（96.97）
χ²值		46.200		1.710
P值		<0.001		0.190