Laboratory Medicine ›› 2015, Vol. 30 ›› Issue (9): 911-915.DOI: 10.3969/j.issn.1673-8640.2015.09.011
• Orginal Article • Previous Articles Next Articles
Received:
2014-12-17
Online:
2015-09-30
Published:
2015-09-29
CLC Number:
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URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2015.09.011
组别 | 例数 | PGⅠ(ng/mL) | PGⅡ(ng/mL) | PGR | GPDA(U/L) |
---|---|---|---|---|---|
胃癌组 | 50 | 67.96±17.24*#Δ▲▲ | 25.27±4.63*#Δ※ | 2.75±0.86*#Δ▲▲ | 54.78±13.16*#Δ▲▲ |
慢性萎缩性胃炎组 | 50 | 89.22±24.39* | 23.37±4.84* | 4.04±1.41* | 65.72±15.26* |
浅表性胃炎组 | 50 | 126.50±31.25Δ▲▲ | 20.36±7.06Δ▲ | 6.43±0.88Δ▲▲ | 75.00±11.97▲▲ |
胃溃疡组 | 50 | 178.22±48.76*▲▲ | 31.77±8.78*▲▲ | 5.73±1.28*▲▲ | 75.34±12.99▲▲ |
正常对照组 | 50 | 132.44±21.96 | 20.77±4.42 | 6.53±1.25 | 74.88±13.53 |
组别 | 例数 | PGⅠ(ng/mL) | PGⅡ(ng/mL) | PGR | GPDA(U/L) |
---|---|---|---|---|---|
胃癌组 | 50 | 67.96±17.24*#Δ▲▲ | 25.27±4.63*#Δ※ | 2.75±0.86*#Δ▲▲ | 54.78±13.16*#Δ▲▲ |
慢性萎缩性胃炎组 | 50 | 89.22±24.39* | 23.37±4.84* | 4.04±1.41* | 65.72±15.26* |
浅表性胃炎组 | 50 | 126.50±31.25Δ▲▲ | 20.36±7.06Δ▲ | 6.43±0.88Δ▲▲ | 75.00±11.97▲▲ |
胃溃疡组 | 50 | 178.22±48.76*▲▲ | 31.77±8.78*▲▲ | 5.73±1.28*▲▲ | 75.34±12.99▲▲ |
正常对照组 | 50 | 132.44±21.96 | 20.77±4.42 | 6.53±1.25 | 74.88±13.53 |
组别 | 例数 | Hp阳性 | |||||||
---|---|---|---|---|---|---|---|---|---|
阳性例数(%) | PGⅠ(ng/mL) | PGⅡ(ng/mL) | PGR | GPDA(U/L) | |||||
胃癌组 | 50 | 38(76) | 66.37±18.86 | 24.52±4.71 | 2.78±0.97 | 54.16±12.01 | |||
浅表性胃炎组 | 50 | 34(68) | 131.41±28.69 | 20.99±6.27 | 6.45±0.97 | 75.00±11.41 | |||
胃溃疡组 | 50 | 40(80) | 180.28±45.94 | 31.60±8.76 | 5.86±1.33 | 75.80±13.36 | |||
慢性萎缩性胃炎组 | 50 | 36(72) | 86.14±21.66 | 22.92±4.16 | 3.99±1.38 | 65.69±13.48 | |||
正常对照组 | 50 | 29(58) | 132.83±18.59 | 20.23±3.99 | 6.75±1.42 | 75.28±13.40 | |||
组别 | 例数 | Hp阴性 | |||||||
阴性例数(%) | PGⅠ(ng/mL) | PGⅡ(ng/mL) | PGR | GPDA(U/L) | |||||
胃癌组 | 50 | 12(24) | 73.00±9.51 | 27.67±3.57 | 2.66±0.34 | 56.75±16.65 | |||
浅表性胃炎组 | 50 | 16(32) | 116.06±34.74 | 19.03±8.58 | 6.38±0.70 | 75.00±13.49 | |||
胃溃疡组 | 50 | 10(20) | 170.01±60.90 | 32.48±9.31 | 5.21±0.93 | 73.50±11.85 | |||
慢性萎缩性胃炎组 | 50 | 14(28) | 97.14±29.75 | 24.53±6.30 | 4.16±1.51 | 67.14±19.26 | |||
正常对照组 | 50 | 21(42) | 131.90±26.41 | 21.52±4.96 | 6.22±0.91 | 74.33±14.03 |
组别 | 例数 | Hp阳性 | |||||||
---|---|---|---|---|---|---|---|---|---|
阳性例数(%) | PGⅠ(ng/mL) | PGⅡ(ng/mL) | PGR | GPDA(U/L) | |||||
胃癌组 | 50 | 38(76) | 66.37±18.86 | 24.52±4.71 | 2.78±0.97 | 54.16±12.01 | |||
浅表性胃炎组 | 50 | 34(68) | 131.41±28.69 | 20.99±6.27 | 6.45±0.97 | 75.00±11.41 | |||
胃溃疡组 | 50 | 40(80) | 180.28±45.94 | 31.60±8.76 | 5.86±1.33 | 75.80±13.36 | |||
慢性萎缩性胃炎组 | 50 | 36(72) | 86.14±21.66 | 22.92±4.16 | 3.99±1.38 | 65.69±13.48 | |||
正常对照组 | 50 | 29(58) | 132.83±18.59 | 20.23±3.99 | 6.75±1.42 | 75.28±13.40 | |||
组别 | 例数 | Hp阴性 | |||||||
阴性例数(%) | PGⅠ(ng/mL) | PGⅡ(ng/mL) | PGR | GPDA(U/L) | |||||
胃癌组 | 50 | 12(24) | 73.00±9.51 | 27.67±3.57 | 2.66±0.34 | 56.75±16.65 | |||
浅表性胃炎组 | 50 | 16(32) | 116.06±34.74 | 19.03±8.58 | 6.38±0.70 | 75.00±13.49 | |||
胃溃疡组 | 50 | 10(20) | 170.01±60.90 | 32.48±9.31 | 5.21±0.93 | 73.50±11.85 | |||
慢性萎缩性胃炎组 | 50 | 14(28) | 97.14±29.75 | 24.53±6.30 | 4.16±1.51 | 67.14±19.26 | |||
正常对照组 | 50 | 21(42) | 131.90±26.41 | 21.52±4.96 | 6.22±0.91 | 74.33±14.03 |
项目 | 最佳临界值 | 灵敏度(%) | 特异度(%) | 阳性预测值(%) | 阴性预测值(%) |
---|---|---|---|---|---|
PGⅠ | 80.50 ng/mL | 66.00 | 76.00 | 70.37 | 73.91 |
PGⅡ | 25.70 ng/mL | 32.00 | 50.00 | 60.98 | 57.63 |
PGR | 3.28 | 72.00 | 90.00 | 76.27 | 87.80 |
GPDA | 57.50 U/L | 72.00 | 62.00 | 68.89 | 65.45 |
项目 | 最佳临界值 | 灵敏度(%) | 特异度(%) | 阳性预测值(%) | 阴性预测值(%) |
---|---|---|---|---|---|
PGⅠ | 80.50 ng/mL | 66.00 | 76.00 | 70.37 | 73.91 |
PGⅡ | 25.70 ng/mL | 32.00 | 50.00 | 60.98 | 57.63 |
PGR | 3.28 | 72.00 | 90.00 | 76.27 | 87.80 |
GPDA | 57.50 U/L | 72.00 | 62.00 | 68.89 | 65.45 |
项目 | AUC | 标准误 | P值 | 95%可信区间 |
---|---|---|---|---|
PGⅠ | 0.763 | 0.048 | 0.000 | 0.669~0.857 |
PGⅡ | 0.397 | 0.056 | 0.075 | 0.286~0.507 |
PGR | 0.801 | 0.046 | 0.000 | 0.710~0.892 |
GPDA | 0. 715 | 0.052 | 0.000 | 0.613~0.817 |
项目 | AUC | 标准误 | P值 | 95%可信区间 |
---|---|---|---|---|
PGⅠ | 0.763 | 0.048 | 0.000 | 0.669~0.857 |
PGⅡ | 0.397 | 0.056 | 0.075 | 0.286~0.507 |
PGR | 0.801 | 0.046 | 0.000 | 0.710~0.892 |
GPDA | 0. 715 | 0.052 | 0.000 | 0.613~0.817 |
项目 | 灵敏度 | 特异度 | 阳性预测值 | 阴性预测值 |
---|---|---|---|---|
PGⅠ并联PGR | 86.00 | 76.00 | 78.18 | 73.33 |
PGⅠ并联GPDA | 76.00 | 70.00 | 76.74 | 61.40 |
PGR并联GPDA | 84.00 | 78.00 | 77.78 | 82.61 |
PGⅠ并联PGR并联GPDA | 92.00 | 72.00 | 85.19 | 78.26 |
项目 | 灵敏度 | 特异度 | 阳性预测值 | 阴性预测值 |
---|---|---|---|---|
PGⅠ并联PGR | 86.00 | 76.00 | 78.18 | 73.33 |
PGⅠ并联GPDA | 76.00 | 70.00 | 76.74 | 61.40 |
PGR并联GPDA | 84.00 | 78.00 | 77.78 | 82.61 |
PGⅠ并联PGR并联GPDA | 92.00 | 72.00 | 85.19 | 78.26 |
[1] | 邱志琦,温少磊,谭智毅.胃蛋白酶原Ⅰ、Ⅱ及其比值在胃癌筛查中的应用[J]. 检验医学与临床,2013,10(14): 1806-1807. |
[2] | 项文坤,熊锋宝,杨铁一,等.血清唾液酸上皮膜抗原及甘氨酰脯氨酸二肽氨基肽酶单项及联合检测诊断胃癌的临床研究[J]. 中国实用内科杂志,2009,29(11):1012-1014. |
[3] | 徐光炜. 新编常见恶性肿瘤诊治规范——胃癌分册[M].北京:北京医科大学中国协和医科大学联合出版社,1999:40-47. |
[4] | 梁军. 血清胃蛋白酶原在胃腺癌诊断中的临床价值[J].全科医学临床与教育,2014,12(3):247-249. |
[5] | KAGEYAMA T.Pepsinogens,progastricsins,and prochymosins: structure,function,evolution,and development[J]. Cell Mol Life Sci,2002,59(2):288-306. |
[6] | 张金锋. 血清胃蛋白酶原、CEA、CA19-9及CA72-4检测对胃癌的诊断价值探讨[J]. 检验医学,2014,29(8): 831-834. |
[7] | 卢灿荣,张士武,张勇,等. 癌胚抗原、糖链抗原72-4和胃蛋白酶原联合检测评价胃癌的诊断价值[J]. 检验医学,2012,27(6): 442-444. |
[8] | 费凤英,王金金,祝新华. 血清胃蛋白酶原检测在胃癌诊治中的应用进展[J].医学信息,2011,24(3):1461-1463. |
[9] | 赵兰静,刘春兴,安仙园. 血清胃蛋白酶原和抗Hp IgG抗体对消化性溃疡的临床意义[J]. 检验医学,2014,29(11): 1124-1127. |
[10] | KONTUREK PC,KONTUREK SJ,BRZOZOWSKI T.Helicobacter pylori infection in gastric cancerogenesis[J]. J Physiol Pharmacol,2009,60(3):3-21. |
[11] | LORENTE S,DOIZ O,TRINIDAD SERRANO M,et al.Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells[J]. Gut,2002,50(1): 13-18. |
[12] | SUN LP,GONG YH,WANG L, et al . Serum pepsinogen levels and their influencing factors: a population-based study in 6 990 Chinese from North China[J]. World J Gastroenterol,2007,13( 48): 6562-6567. |
[13] | OISHI Y,KIYOHARA Y,KUBO M,et al.The serum pepsinogen test as a predictor of gastric cancer: the Hisayama study[J]. Am J Epidemiol,2006,163(7):629-637. |
[14] | 赵瑶,刘银梅,胡文斌,等. 胃蛋白酶原在癌前病变、胃癌诊断中的应用进展[J]. 实用癌症杂志,2011,26(2):205-207. |
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