Investigation of HCV co-infection among HIV-1 infected patients in Dali city

Abstract

Abstract: Objective　To investigate the ratio of hepatitis C virus (HCV) coinfection and the impact of HCV co-infection on CD4⁺T cell counts in human immunodeficiency virus 1 (HIV-1)-infected patients. Methods　A crosssectional study was performed among HIV-1infected patients for assessment of HCV co-infection determination with serology and nucleic acid test in Dali Yunnan. Results　Among 526 HIV-1infected patients， the injecting drug users accounted for 94.3%, and the others were infected through sex. The percentage of anti HCVIgG positive was 86.9％(457/526)， and the positive accordant rate of HCV RNA and anti HCV-IgG was 78.3%. However，HCV RNA >1 000 IU/mL was detected in 24 patients out of 69 anti HCV-IgG negative patients. As for HCV nucleic acid test, the detection rate of HCV coinfection increased 4.6% (24/526). The ratio of HCV co-infection was 91.4%. The CD4⁺T cell counts among single HIV-1 infection were significantly higher than those among HCV co-infection. Conclusions　The ratio of HIV-1/HCV infection is high in highrisk areas or population， and the determination of HCV during screening HIV-1 infection may help for the early diagnosis and treatment of HCV and decrease the effect of HIV-1 infection patients.

Key words: Human immunodeficiency virus 1, Hepatitis C virus, Nucleic acid test, Coinfection, CD4⁺T cell count

ZHANG Haiyan;WANG Wanhai;XIA Xueshan;WANG Yongheng;FENG Yue;SU Tianrong;ZHANG Xiaoyan. Investigation of HCV co-infection among HIV-1 infected patients in Dali city[J]. , 2012, 27(2): 141-144.

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