The study progress of false positivity in screening assay for detecting anti-HCV antibody and anti-TP antibody and its strategy

doi:10.3969/j.issn.1673-8640.2015.12.002

Abstract

Abstract:

There is a certain proportion of false positivity in screening assay for detecting anti-hepatitis C virus (HCV)antibody and anti-treponema pallidum(TP)antibody by enzyme-linked immunosorbent assay (ELISA) or chemiluminescence immunoassay (CLIA). Therefore, it is required to report positive results by confirmation assay . It is an alternative strategy for reducing false positive rate as far as possible in detecting anti-HCV antibody and anti-TP antibody by ELISA and CLIA and making the application of confirmation assay economic and rational by determining the signal-to-cut off (S/CO) ratio, when the positive predictive value of screening assay results reaches 95% with certain detection reagent (system) and in certain population.

Key words: Anti-hepatitis C virus antibody, Anti-treponema pallidum antibody, Screening assay, False positivity, Confirmation assay

CLC Number:

R446.61

CHEN Cuncun, FAN Lieying.. The study progress of false positivity in screening assay for detecting anti-HCV antibody and anti-TP antibody and its strategy[J]. Laboratory Medicine, 2015, 30(12): 1167-1174.

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