›› 2013, Vol. 28 ›› Issue (9): 805-808.DOI: 10.3969/j.issn.1673-8640.2013.09.017

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Study on the correlationship of ferritin concentration with insulin resistance in patients with type 2 diabetes mellitus

XU Jing,HU Xiaobo.   

  1. Department of Clinical Laboratory, Shanghai Third People′s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201900,China
  • Received:2013-05-07 Revised:2013-09-25 Online:2013-09-15 Published:2013-09-25

Abstract:

Objective To investigate the relationship of serum ferritin (SF) with type 2 diabetes mellitus (T2DM) in Chinese Han population with different ages. Methods A total of 100 patients with T2DM (T2DM group),100 patients with high ferritin and non-T2DM (high SF group) and 100 healthy subject controls (control group) were enrolled for the determinations of fasting blood glucose (FBG),fasting insulin (FINS),SF and glycosylated hemoglobin (HbA1c) and blood parameters [hemoglobin (Hb),hematocrit (Hct),mean corpuscular volume (MCV) and mean cell hemoglobin (MCH)]. The correlationship was analyzed. Results The SF,FBG,HbA1c,FINS and homeostasis model assessment of insulin resistance (HOMR-IR) in T2DM group were significantly higher than those in control group (P<0.05). SF had a significant correlation with FBG ,HbA1c ,FINS and HOMR-IR (r=0.140, 0.171, 0.189 and 0.316,P=0.003,0.023,0.004 and 0.001). The Hb, FBG, HbA1C, FINS and HOMA-IR in T2DM group were significantly higher than those in high SF group (P<0.05). The SF and MCV in high SF group were significantly higher than those in control group (P<0.05). Conclusions Iron overload leads to the increasing of SF, which is correlated with insulin resistance in patients with T2DM.

Key words: Serum ferritin, Insulin resistance, Type 2 diabetes mellitus

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