Abstract: Objective　To investigate the relationship of thrombelastograph (TEG) parameters with fibrinogen（Fg） in patients with cerebrovascular disease.   Methods　A total of 470 patients with cerebrovascular disease［70 patients with cavity infarction and 400 patients with cerebral infarction（73 patients with pure cerebral infarction，200 cerebral infarction patients with high blood pressure，27 cerebral infarction patients with diabetes mellitus and 100 cerebral infarction patients with high blood pressure and diabetes mellitus）］ and 50 healthy controls were enrolled. TEG-5000 TEG analyzer （TEG-5000） was used to determine the parameters of K value，angle （A） value and MA value. The Fg level was detected by ACL-TOP automatic blood coagulation analyzer. The platelet （PLT） count and mean platelet volume（MPV）were detected by LH 750 automatic blood analyzer. Results　There was negative correlation between Fg level and K value（r＝－0.134，P=0.000）. There was positive correlation between Fg level and A value，MA value and PLT count（r＝0.210，P=0.000；r＝0.251，P=0.000；r＝0.122，P=0.000）. There was no correlation between Fg level and MPV（r＝－0.007; P=0.957）. The A value，MA value，PLT count and Fg level in cavity infarction group and cerebral infarction group were higher than those in the control group（P＜0.05，P<0.01）. MPV value in cerebral infarction group was higher than that in the control group（P＜0.05）, but there was no statistical significance between cavity infarction group and the control group (P>0.05). The K value had no statistical significance among cavity infarction group，cerebral infarction group and the control group (P>0.05). The MA value in cerebral infarction patients with diabetes mellitus was higher than that in patients with pure cerebral infarction and cerebral infarction patients with high blood pressure（P＜0.05）. The Fg levels in cerebral infarction patients with oliabetes mellitus and cerebral infarction patients with diabetes mellitus and high blood pressure were higher than those in cerebral infarction patients with high blood pressure（P＜0.05）. The other parameters had no difference between each group. Conclusions　In the process of cerebrovascular disease，there are changes of PLT quantity，quality，form and Fg level. Fg and TEG parameters have obvious correlation. TEG determination with the practical value can be one of the screening tests for cerebrovascular disease.

Key words: Thrombelastograph, Fibrinogen, Platelet count, Mean platelet volume, Cerebrovascular disease