doi:10.3969/j.issn.1673-8640.2026.07.014

Abstract

CLC Number:

R378.99

Figures/Tables 8

References 20

[1]	张晶, 王占黎, 李星男, 等. 人类布鲁氏菌病流行病学研究进展[J]. 中国感染控制杂志, 2023, 22(2):239-243.
[2]	布鲁氏菌病诊疗方案(2023年版)[J]. 中国感染控制杂志, 2024, 23(5):661-664.
[3]	王太武, 韩一芳, 曹勇平, 等. 2005—2020年我国布鲁菌病发病率年龄时期队列分析及趋势预测[J]. 中国预防医学杂志, 2024, 25(11):1382-1387.
[4]	Guo X, Zeng H, Li M, et al. The mechanism of chronic intracellular infection with Brucella spp[J]. Front Cell Infect Microbiol, 2023, 13:1129172. DOI URL
[5]	Qiangsheng F, Xiaoqin H, Tong L, et al. Brucella cultures characteristics,clinical characteristics,and infection biomarkers of human brucellosis[J]. J Infect Public Health, 2023, 16(3):303-309. DOI URL
[6]	Spernovasilis N, Karantanas A, Markaki I, et al. Brucella spondylitis:current knowledge and recent advances[J]. J Clin Med, 2024, 13(2):595. DOI URL
[7]	李钊, 张友文, 姜鲁宁. 72例布鲁菌病患者临床特征分析[J]. 中华地方病学杂志, 2018, 37(10):822-825.
[8]	Li L M, Wang Q, Shi J F, et al. Seroprevalence and potential risk factors of brucellosis in sheep from America,Africa and Asia regions:a systematic review and meta-analysis[J]. Res Vet Sci, 2023, 165:105048. DOI URL
[9]	王莹, 郭伟泉, 向媛媛, 等. 2004—2015年甘肃省人间布鲁氏菌病与气象因素的相关性[J]. 中国动物检疫, 2022, 39(1):18-22.
[10]	郭珂宇, 关鹏, 单连峰, 等. 2013至2021年我国人布鲁氏菌病发病重心轨迹特征分析[J]. 中国医科大学学报, 2023, 52(8):680-683.
[11]	Buzgan T, Karahocagil M K, Irmak H, et al. Clinical manifestations and complications in 1 028 cases of brucellosis:a retrospective evaluation and review of the literature[J]. Int J Infect Dis, 2010, 14(6):e469-e478.
[12]	Bzeizi K I, Benmousa A, Sanai F M. Coincidence of acute Brucella hepatitis and dengue fever or serologic cross-reactivity?[J]. Saudi J Gastroenterol, 2010, 16(4):299-301. DOI URL
[13]	吴志国, 徐慧丽, 罗小露, 等. 布鲁菌病35例临床特征分析[J]. 中国感染与化疗杂志, 2021, 21(2):181-184. DOI
[14]	赵旭春, 刘颖翰, 王玮, 等. 125例成人急性布鲁氏菌病患者的肝功能异常临床分析[J]. 中国地方病防治, 2010, 25(1):68-69.
[15]	贾斌, 张峰波, 朱玥洁, 等. 血液检出布鲁氏菌阳性患者的实验室及临床特点分析[J]. 新疆医科大学学报, 2017, 40(2):136-140.
[16]	宋仕玲, 祝捷, 曾芙蓉, 等. 深圳市39例急性期布鲁菌病患者临床特征分析[J]. 中华地方病学杂志, 2019, 38(9):739-742.
[17]	李华, 张志伟, 高晓娟, 等. 河南省99例布鲁菌病患者临床特征分析[J]. 中华地方病学杂志, 2018, 37(5):402-405.
[18]	Liu J, Zhao X. Clinical features and serum profile of inflammatory biomarkers in patients with brucellosis[J]. J Infect Dev Ctries, 2017, 11(11):840-846. DOI URL
[19]	Xu N, Dong X, Yao Y, et al. Improved early detection of focal brucellosis complications with anti-Brucella IgG[J]. J Clin Microbiol, 2020, 58(10):e00903-20.
[20]	Yetkin M A, Erdinc F S, Bulut C, et al. Epididymoorchitis due to brucellosis in central Anatolia,Turkey[J]. Urol Int, 2005, 75(3):235-238. DOI URL

首发症状	例数	百分比/%
发热伴
呼吸道症状	10	20
单纯性发热	9	18
关节疼痛	7	14
胃肠道症状	4	8
乏力、纳差	5	10
非发热伴
关节疼痛	9	18
乏力、纳差	4	8
胃肠道症状	2	4

首发症状	例数	百分比/%
发热伴
呼吸道症状	10	20
单纯性发热	9	18
关节疼痛	7	14
胃肠道症状	4	8
乏力、纳差	5	10
非发热伴
关节疼痛	9	18
乏力、纳差	4	8
胃肠道症状	2	4

项目	例数	百分比/%
虎红平板凝集试验阳性	50	100
试管凝集试验阳性
1∶100~1∶200	12	24
1∶400~1∶800	29	58
>1∶800	9	18
CRP>10 mg·L^-1	41	82
ESR>15 mm·h^-1	30	60
ALT>40 U·L^-1	19	38
AST>40 U·L^-1	15	30
PCT>0.5 ng·mL^-1	7	14
WBC计数>9.5×10⁹L^-1	4	8
Alb<40 g·L^-1	33	66
Hb（男性<130 g·L^-1，女性<115 g·L^-1）	29	58
TP<65 g·L^-1	20	40
PLT计数<115×10⁹L^-1	12	24

项目	例数	百分比/%
虎红平板凝集试验阳性	50	100
试管凝集试验阳性
1∶100~1∶200	12	24
1∶400~1∶800	29	58
>1∶800	9	18
CRP>10 mg·L^-1	41	82
ESR>15 mm·h^-1	30	60
ALT>40 U·L^-1	19	38
AST>40 U·L^-1	15	30
PCT>0.5 ng·mL^-1	7	14
WBC计数>9.5×10⁹L^-1	4	8
Alb<40 g·L^-1	33	66
Hb（男性<130 g·L^-1，女性<115 g·L^-1）	29	58
TP<65 g·L^-1	20	40
PLT计数<115×10⁹L^-1	12	24

项目	A组	B组	P值
CRP	28.90（16.68，60.56）	2.65（0.9，11.2）	<0.001
ESR	19.50（15.00，32.00）	12.00（7.75，19.00）	<0.001
Alb	35.30（32.70，41.90）	42.00（38.20，45.00）	<0.001

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Figures/Tables 8

References 20

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Metrics

项目	AUC（95%CI^①）	敏感性/%	特异性/%
CRP	0.888（0.825~0.951）	0.82	0.72
Alb	0.738（0.644~0.838）	0.54	0.88
ESR	0.726（0.627~0.824）	0.78	0.56
3项指标联合	0.878（0.808~0.942）	0.72	0.92

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