doi:10.3969/j.issn.1673-8640.2026.07.013

Abstract

CLC Number:

R373.9

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References 19

[1]	Damania B, Kenney S C, Raab-traub N. Epstein-barr virus:biology and clinical disease[J]. Cell, 2022, 185:3652-3670. DOI URL
[2]	郭建巍. EB病毒感染的核酸检测:标本类型的选择[J]. 分子诊断与治疗杂志, 2016, 8(3):145-149.
[3]	谢正德. 儿童EB病毒传染性单核细胞增多症临床特征及诊断标准[J]. 实用儿科临床杂志, 2007, 22(22):1759-1760.
[4]	中华医学会儿科学分会感染学组, 全国儿童EB病毒感染协作组, 申昆玲. 儿童EB病毒感染相关疾病的诊断和治疗原则专家共识[J]. 中华儿科杂志, 2021, 59(11):905-911.
[5]	Barrett T M, Liebert M A, Eick G N, et al. Circulating epstein-barr virus antibody levels as a biomarker of socioecological adversity in amazonian ecuador[J]. Am J Hum Biol, 2025, 37(5):e70063. DOI URL
[6]	Verougstraete N, Padalko E, Coorevits L. Interpretation of EBV serology for human body material donors:is there a need for early antigen IgG and heterophile antibodies testing?[J]. Cell Tissue Bank, 2020, 21(1):167-169. DOI PMID
[7]	Yue M, Li J, Li J, et al. Comparative analysis of the immune repertoire between peripheral blood and bone marrow fluids in those infected by EBV and immunodeficiency:a retrospective case study[J]. Medicine(Baltimore), 2024, 103(38):e39501.
[8]	刘春艳, 闫静, 刘亚谊, 等. EB病毒相关性传染性单核细胞增多症的血清学诊断[J]. 中华流行病学杂志, 2007, 28(9):898-900.
[9]	Yan Z, Yao Z, Wang H, et al. Plasma EBV-DNA and peripheral blood mononuclear cell EBV-DNA have disparate clinical relevance in patients with extranodal NK/T-cell lymphoma[J]. J Clin Virol, 2022, 157:105320. DOI URL
[10]	Zhou X, Lu X, He J, et al. Clinical value of plasma and peripheral blood mononuclear cells Epstein-Barr virus DNA dynamics on prognosis of allogeneic stem cell transplantation[J]. Front Cell Infect Microbiol, 2022, 12:1-11.
[11]	Zhang W, Yin Y, Li Y, et al. Clinical utility of plasma Epstein-Barr virus DNA monitoring in pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis:a Chinese retrospective observational study[J]. Ital J Pediatr, 2024, 50(1):139. DOI
[12]	张雨涵, 李飞, 周圆圆, 等. 儿童EB病毒原发性感染血浆病毒DNA拷贝数特征[J]. 中华儿科杂志, 2023, 61(3):245-249.
[13]	曾文, 麦荣嘉, 邓文喻, 等. 儿童传染性单核细胞增多症临床特点和PBMC病毒载量在预后的评估价值[J]. 现代医院, 2021, 21(7):1132-1135.
[14]	晏文. 发热儿童血浆EBV DNA载量与EBV感染后相关疾病的临床特征分析[D]. 新乡: 新乡医学院, 2023.
[15]	苏曦, 周琰, 沈敏娜, 等. 不同样本类型对EBV DNA检测结果的影响[J]. 检验医学, 2020, 35(8):803-805. DOI
[16]	Desimio M G, Covino D A, Rivalta B, et al. The role of NK cells in EBV infection and related diseases:current understanding and hints for novel therapies[J]. Cancers(Basel), 2023, 15(6):1914.
[17]	Tsotridou E, Hatzipantelis E. Epstein-Barr infection,Hodgkin's lymphoma,and the immune system:insights into the molecular mechanisms facilitating immune evasion[J]. Cancers(Basel), 2025, 17(9):1481.
[18]	Liu L, Yang X, Li M, et al. EBV-DNA load:a predictor of immune and hepatic dysfunction in pediatric infectious mononucleosis[J]. Diagn Microbiol Infect Dis, 2025, 113(1):116897. DOI URL
[19]	Li Y, Tang J, Ma Y, et al. Clinical significance and pathogenesis of GBP5 in infectious mononucleosis associated liver injury[J]. Ital J Pediatr, 2025, 51(1):72. DOI PMID

项目	例数	百分比/%
临床症状
发热	184	100.00
咽痛	184	100.00
眼睑水肿	112	60.87
颈部淋巴结肿大	152	82.81
肝脏大	35	19.02
脾脏大	139	75.54
EBV相关抗体
EBV-CA-IgM抗体阳性	184	100.00
EBV-CA-IgG抗体阳性	178	96.70
EBV-EA-IgG抗体阳性	69	37.50
EBV-NA-IgG抗体阳性	0	0

项目	例数	百分比/%
临床症状
发热	184	100.00
咽痛	184	100.00
眼睑水肿	112	60.87
颈部淋巴结肿大	152	82.81
肝脏大	35	19.02
脾脏大	139	75.54
EBV相关抗体
EBV-CA-IgM抗体阳性	184	100.00
EBV-CA-IgG抗体阳性	178	96.70
EBV-EA-IgG抗体阳性	69	37.50
EBV-NA-IgG抗体阳性	0	0

组别	例数	PBMC		血浆
组别	例数	阳性/[例（%）]	阴性/[例（%）]	阳性/[例（%）]	阴性/[例（%）]
IM组	184	184（100.0）	0（0）	62（33.7）	122（66.3）
对照组	205	24（11.7）	181（88.3）	0（0）	205（100.0）
χ²值		303.048		81.962
P值		<0.001		<0.001

组别	例数	PBMC		血浆
组别	例数	阳性/[例（%）]	阴性/[例（%）]	阳性/[例（%）]	阴性/[例（%）]
IM组	184	184（100.0）	0（0）	62（33.7）	122（66.3）
对照组	205	24（11.7）	181（88.3）	0（0）	205（100.0）
χ²值		303.048		81.962
P值		<0.001		<0.001

组别	例数	PBMC/（拷贝·mL^-1）	血浆/（拷贝·mL^-1）
IM组	184	201 950（33 500，500 750）	0（0，1 105）^*
对照组	205	0（0，0）	0（0，0）
Z值		-17.814	-9.903
P值		<0.001	<0.001

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组别	例数	PBMC/（拷贝·mL^-1）	血浆/（拷贝·mL^-1）
肝功能正常组	68	52 790（17 245，281 950）	0（0，0）
肝功能异常组	116	257 200（54 260，927 600）	0（0，1 657）
Z值		-2.282	-2.622
P值		0.023	0.009

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