Roles of serum VCAM-1，Gal-3 and Hcy expression levels in evaluating patients with coronary heart disease

doi:10.3969/j.issn.1673-8640.2025.03.008

Abstract

Abstract:

Objective To investigate the changes and value of vascular cell adhesion molecule-1（VCAM-1），galectin-3（Gal-3）and homocysteine（Hcy）levels in patients with coronary heart disease（CHD）. Methods From February 2023 to July 2024，118 patients diagnosed with CHD by coronary angiography （CHD group）and 120 healthy subjects（healthy control group）were enrolled at Shanghai Electric Power Hospital. The CHD patients were classified based on CHD types，coronary angiography results and New York Heart Association（NYHA） classification criteria. The clinical data were collected，and the levels of VCAM-1，Gal-3，Hcy，glucose（Glu），high-density lipoprotein cholesterol（HDL-C），low-density lipoprotein cholesterol（LDL-C），triglyceride（TG）and total cholesterol（TC）were determined. Spearman correlation analysis was used to assess the relationship between variables. Multivariate Logistic regression analysis was used to evaluate the risk factors for CHD，and receiver operating characteristic（ROC）curve was used to evaluate the efficacy of each indicator in the diagnosis of CHD. Results The smoking history，body mass index（BMI）and serum levels of VCAM-1，Gal-3，Hcy，Glu，LDL-C，TC and TG in CHD group were higher than those in control group（P<0.05），while the serum level of HDL-C was lower（P<0.05）. The serum levels of VCAM-1，Gal-3 and Hcy in stable angina pectoris（SAP）group，unstable angina pectoris（UAP）group and acute myocardial infarction（AMI）group were increased in turn（P<0.001）. The serum levels of VCAM-1，Gal-3 and Hcy in mild stenosis group，moderate stenosis group and severe stenosis group were increased in turn（P<0.01）. The serum levels of VCAM-1，Gal-3 and Hcy in NYHA class Ⅰ+Ⅱ group，NYHA class Ⅲ group and NYHA class Ⅳ group were increased in turn（P<0.001）. Serum VCAM-1，Gal-3 and Hcy levels were positively correlated with the degree of coronary artery stenosis and NYHA classification （P<0.05）. Increased VCAM-1，Gal-3，Hcy，BMI，Glu，smoking history，TC，TG，LDL-C and decreased HDL-C were risk factors for CHD （P<0.05）. The areas under curves （AUC） of single and combined determinations of serum VCAM-1，Gal-3 and Hcy in the diagnosis of CHD were 0.856，0.845，0.873 and 0.952，respectively. Conclusions Serum levels of VCAM-1，Gal-3 and Hcy in patients with CHD are related to the types and severity of CHD，and may be used as biomarkers for CHD assessment.

Key words: Vascular cell adhesion molecule-1, Galectin-3, Homocysteine, Coronary heart disease

CLC Number:

R446.1

SHU Ming. Roles of serum VCAM-1，Gal-3 and Hcy expression levels in evaluating patients with coronary heart disease[J]. Laboratory Medicine, 2025, 40(3): 247-252.

Figures/Tables 8

References 20

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组别	例数	年龄/岁	性别		BMI/ （kg·m^-2）	吸烟史/ [例（%）]	Glu/ （mmol·L^-1）	HDL-C/（mmol·L^-1）
组别	例数	年龄/岁	男/例	女/例	BMI/ （kg·m^-2）	吸烟史/ [例（%）]	Glu/ （mmol·L^-1）	HDL-C/（mmol·L^-1）
CHD组	118	63.42±14.56	65	53	23.84±2.34	57（48.31）	6.48±1.64	1.36±0.29
正常对照组	120	62.81±13.69	69	51	20.82±2.22	40（33.33）	4.94±0.75	1.68±0.39
统计值		0.62	0.141		10.22	5.52	9.27	6.94
P值		0.54	0.707		<0.001	0.019	<0.001	<0.001
组别	LDL-C/（mmol·L^-1）		TC/（mmol·L^-1）		TG/（mmol·L^-1）	VCAM-1/（pg·mL^-1）	Gal-3/（ng·mL^-1）	Hcy/（µmol·L^-1）
CHD组	3.15±0.74		6.11±0.74		1.33±0.54	804.35（624.67~989.76）	4.15（2.26~6.16）	20.73±5.75
正常对照组	2.51±0.56		4.64±1.00		0.72±0.24	425.46（246.38~595.29）	1.23（0.68~2.29）	9.71±2.36
统计值	7.55		12.92		11.25	14.18	12.44	19.40
P值	<0.001		<0.001		<0.001	<0.001	<0.001	<0.001

组别	例数	年龄/岁	性别		BMI/ （kg·m^-2）	吸烟史/ [例（%）]	Glu/ （mmol·L^-1）	HDL-C/（mmol·L^-1）
组别	例数	年龄/岁	男/例	女/例	BMI/ （kg·m^-2）	吸烟史/ [例（%）]	Glu/ （mmol·L^-1）	HDL-C/（mmol·L^-1）
CHD组	118	63.42±14.56	65	53	23.84±2.34	57（48.31）	6.48±1.64	1.36±0.29
正常对照组	120	62.81±13.69	69	51	20.82±2.22	40（33.33）	4.94±0.75	1.68±0.39
统计值		0.62	0.141		10.22	5.52	9.27	6.94
P值		0.54	0.707		<0.001	0.019	<0.001	<0.001
组别	LDL-C/（mmol·L^-1）		TC/（mmol·L^-1）		TG/（mmol·L^-1）	VCAM-1/（pg·mL^-1）	Gal-3/（ng·mL^-1）	Hcy/（µmol·L^-1）
CHD组	3.15±0.74		6.11±0.74		1.33±0.54	804.35（624.67~989.76）	4.15（2.26~6.16）	20.73±5.75
正常对照组	2.51±0.56		4.64±1.00		0.72±0.24	425.46（246.38~595.29）	1.23（0.68~2.29）	9.71±2.36
统计值	7.55		12.92		11.25	14.18	12.44	19.40
P值	<0.001		<0.001		<0.001	<0.001	<0.001	<0.001

组别	例数	VCAM-1/（pg·mL^-1）	Gal-3/（ng·mL^-1）	Hcy/（µmol·L^-1）
SAP组	40	612.54（498.86~813.56）	2.64（1.56~3.64）	10.15±2.93
UAP组	38	815.76（675.53~937.89）*	3.89（3.12~4.69）*	17.94±3.42*
AMI组	40	934.75（823.23~1 098.78）*#	4.91（4.15~6.25）*#	21.97±3.67*#
统计值		34.352	12.537	13.674
P值		<0.001	<0.001	<0.001

组别	例数	VCAM-1/（pg·mL^-1）	Gal-3/（ng·mL^-1）	Hcy/（µmol·L^-1）
SAP组	40	612.54（498.86~813.56）	2.64（1.56~3.64）	10.15±2.93
UAP组	38	815.76（675.53~937.89）*	3.89（3.12~4.69）*	17.94±3.42*
AMI组	40	934.75（823.23~1 098.78）*#	4.91（4.15~6.25）*#	21.97±3.67*#
统计值		34.352	12.537	13.674
P值		<0.001	<0.001	<0.001

组别	例数	VCAM-1/（pg·mL^-1）	Gal-3/（ng·mL^-1）	Hcy/（µmol·L^-1）
轻度狭窄组	46	604.32（486.97~785.84）	2.47（1.51~3.55）	14.64±2.75
中度狭窄组	39	786.98（642.87~908.96）*	3.76（3.03~4.54）*	17.43±3.31*
重度狭窄组	33	927.00（811.54~1 045.87）*#	4.86（4.06~6.07）*#	20.99±3.64*#
统计值		32.321	11.564	9.263
P值		<0.001	<0.001	0.003