Clinical significance of serum lncRNA NEAT1 for multiple myeloma patients with kidney injury

doi:10.3969/j.issn.1673-8640.2025.01.006

Abstract

Abstract:

Objective To analyze the clinical application value of serum long non-coding RNA（lncRNA）nuclear paraspeckle assembly transcript 1（NEAT1）for multiple myeloma（MM） patients with kidney injury. Methods A total of 107 newly diagnosed MM patients admitted to Shanghai General Hospital of Shanghai Jiao Tong University School of Medicine from January 2020 to April 2023 were enrolled as MM group，and 60 healthy subjects were enrolled as control group. According to whether MM patients were complicated with kidney injury，they were classified into kidney injury group （36 cases） and non-kidney injury group （71 cases）. The 71 patients with non-kidney injury were followed up for 1 year，19 patients with late kidney injury were enrolled in late kidney injury group，and the remaining 52 patients were enrolled in late non-kidney injury group. The expression of serum lncRNA NEAT1 in each group was determined and compared，and the factors that may affect MM complicated with kidney injury were analyzed by Logistic regression analysis. The predictive value of serum lncRNA NEAT1 for MM complicated with kidney injury was evaluated by receiver operating characteristic （ROC） curve. Results The relative expression level of serum lncRNA NEAT1 in MM group was higher than that in control group （P<0.05）. The proportion of light chain type，Durie-Salmon（DS）stageⅢ，the International Staging System（ISS）stageⅢ and serum creatinine（SCr）level in kidney injury group were higher than those in non-kidney injury group （P<0.05）. The relative expression level of serum lncRNA NEAT1 in kidney injury group was higher than that of non-kidney injury group（P<0.05）. ISS stageⅢ，SCr，DS stageⅢ and lncRNA NEAT1 were the factors affecting the occurrence of kidney injury in patients with MM. The relative expression of serum lncRNA NEAT1 in patients with MM complicated with kidney injury was positively correlated with SCr level（r=0.376，P<0.05）. The relative expression level of lncRNA NEAT1 in late kidney injury group was higher than that in late non-kidney injury group （P<0.05）. Conclusions The relative expression level of serum lncRNA NEAT1 in patients with MM complicated with kidney injury is increased，and serum lncRNA NEAT1 level is related to the severity of kidney injury. Serum lncRNA NEAT1 has a good clinical application value for kidney injury in patients with MM.

Key words: Long non-coding RNA, Nuclear paraspeckle assembly transcript 1, Multiple myeloma, Kidney injury

CLC Number:

R446.7

SHEN Ximin, ZHANG Lei, QUAN Heng, NIU Ziguang, XIA Dongge, ZHANG Rulin. Clinical significance of serum lncRNA NEAT1 for multiple myeloma patients with kidney injury[J]. Laboratory Medicine, 2025, 40(1): 32-36.

Figures/Tables 5

References 19

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组别	例数	lncRNA NEAT1	SCr/ （μmol·L^-1）
MM组	108	1.681±0.333	164.71±49.20
健康对照组	60	1.033±0.252	107.02±31.62
t值		13.123	8.186
P值		<0.001	<0.001

组别	例数	lncRNA NEAT1	SCr/ （μmol·L^-1）
MM组	108	1.681±0.333	164.71±49.20
健康对照组	60	1.033±0.252	107.02±31.62
t值		13.123	8.186
P值		<0.001	<0.001

组别	例数	性别		年龄/岁	合并基础性疾病/ [例（%）]	轻链型/ [例（%）]	DS-Ⅲ期/ [例（%）]	ISS-Ⅲ期/[例（%）]	SCr/ （μmol·L^-1）	lncRNA NEAT1
组别	例数	男/例	女/例	年龄/岁	合并基础性疾病/ [例（%）]	轻链型/ [例（%）]	DS-Ⅲ期/ [例（%）]	ISS-Ⅲ期/[例（%）]	SCr/ （μmol·L^-1）	lncRNA NEAT1
肾损伤组	36	20	16	65.05±10.39	5（13.89）	11（30.56）	15（41.67）	17（47.22）	218.42±57.32	1.984±0.330
非肾损伤组	71	36	35	66.32±8.41	9（12.68）	6（8.45）	5（7.04）	9（12.67）	137.48±35.40	1.551±0.217
统计值		0.225		0.681	0.016	8.734	18.843	15.498	9.003	8.134
P值		0.635		0.498	0.898	0.003	<0.001	<0.001	<0.001	<0.001

组别	例数	性别		年龄/岁	合并基础性疾病/ [例（%）]	轻链型/ [例（%）]	DS-Ⅲ期/ [例（%）]	ISS-Ⅲ期/[例（%）]	SCr/ （μmol·L^-1）	lncRNA NEAT1
组别	例数	男/例	女/例	年龄/岁	合并基础性疾病/ [例（%）]	轻链型/ [例（%）]	DS-Ⅲ期/ [例（%）]	ISS-Ⅲ期/[例（%）]	SCr/ （μmol·L^-1）	lncRNA NEAT1
肾损伤组	36	20	16	65.05±10.39	5（13.89）	11（30.56）	15（41.67）	17（47.22）	218.42±57.32	1.984±0.330
非肾损伤组	71	36	35	66.32±8.41	9（12.68）	6（8.45）	5（7.04）	9（12.67）	137.48±35.40	1.551±0.217
统计值		0.225		0.681	0.016	8.734	18.843	15.498	9.003	8.134
P值		0.635		0.498	0.898	0.003	<0.001	<0.001	<0.001	<0.001

因素	β值	标准误	χ²值	P值	OR^①值（95%CI^②）
ISS-Ⅲ期	1.748	0.335	27.227	<0.001	5.743（2.978~11.074）
SCr	1.450	0.338	18.404	<0.001	4.263（2.198~8.269）
DS-Ⅲ期	1.394	0.428	10.608	0.001	4.031（1.742~9.327）
lncRNA NEAT1	1.242	0.492	6.373	0.012	3.463（1.320~9.082）