Abstract:

Objective To analyze cytoplasmic inclusions in plasma cells of multiple myeloma,that will be useful for the morphological diagnosis of multiple myeloma with abnormal plasma cells. Methods A rare kind of plasma cells was found in the bone marrow smear of κ light chain multiple myeloma using Wright-Giemsa staining. The case was analyzed retrospectively,and the relevant literatures in Pubmed were searched. Results Abnormal plasma cell cytoplasma in this case showed obvious,different-sized,irregular and purple-red granules. The granules in this case may be azurophilic granules. Russell bodies,Mott cells,Dutcher bodies and Auer rod-like inclusions were common intra-cytoplasmic inclusions in plasma cells. These inclusions may play roles in clinic. Conclusions The morphological diagnosis of multiple myeloma with abnormal plasma cells plays a role in the diagnosis of light chain multiple myeloma or multiple myeloma with abnormal plasma cell inclusions.

Key words: Plasma cell, Azurophilic granule, Morphological diagnosis, Light chain multiple myeloma