Clinical characteristics of acute lymphoblastic leukemia children infected with Epstein-Barr virus

doi:10.3969/j.issn.1673-8640.2024.06.012

Abstract

Abstract:

Objective To investigate the clinical characteristics of children with acute lymphoblastic leukemia（ALL） infected by Epstein-Barr（EB） virus，and to provide a reference for clinical intervention. Method A total of 90 ALL children aged ≤17 years hospitalized in Hebei Children's Hospital from January 2020 to August 2022 were enrolled and classified into infected group（78 cases） and uninfected group（12 cases） according to whether they were infected with EB virus. The clinical data of 2 groups of children were collected. Serum EB virus antibody profile [anti-EB virus capsid antibody IgM（EBV-CAIgM），anti-EB virus early antibody IgG（EBV-EAIgG），anti-EB virus capsid antibody IgG（EBV-CAIgG），anti-EB virus nuclear antibody IgG（EBV-NA₁IgG）] was determined by enzyme-linked immunosorbent assay. The clinical characteristics and various indexes of the 2 groups were compared. Results There was no statistical significance in gender and age between infected and uninfected groups （P>0.05）. Among children with T-acute lymphoblastic leukemia （T-ALL），70.59% （12/17） cases were infected with EB virus，while among children with B-acute lymphoblastic leukemia （B-ALL），90.41%（66/73） cases were infected with EB virus. The difference in the proportion of EB virus infection between children with different immunophenotypes was not statistically significant （P>0.05）. The proportions of previous infections among children with B-ALL and T-ALL were high （>45%）. Conclusions The proportion of EB virus infection in children with ALL is high. Clinical screening and monitoring of EB virus infection in ALL patients should be strengthened.

Key words: Epstein-Barr virus, Acute lymphoblastic leukemia, Children

CLC Number:

R373.9

YAN Jianghong, WANG Le, MA Lin, YANG Shuo, GUO Weiwei, ZHAO Mengchuan, LIU Zehao, ZHAI Xiaoying. Clinical characteristics of acute lymphoblastic leukemia children infected with Epstein-Barr virus[J]. Laboratory Medicine, 2024, 39(6): 583-586.

Figures/Tables 2

References 17

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项目	EB病毒感染/ [%（例/例）]	无EB病毒感染/ [%（例/例）]
T-ALL（17例）	70.59（12/17）	29.41（5/17）
B-ALL（73例）	90.41（66/73）	9.59（7/73）
χ²值	3.130
P值	0.077

项目	EB病毒感染/ [%（例/例）]	无EB病毒感染/ [%（例/例）]
T-ALL（17例）	70.59（12/17）	29.41（5/17）
B-ALL（73例）	90.41（66/73）	9.59（7/73）
χ²值	3.130
P值	0.077

EBV-CA-IgM	EBV-CA-IgG	EBV-EA-IgG	EBV-NA₁-IgG	B-ALL/例	T-ALL/例
-	-	-	-	7	5
+	+	-	-	3	4
+	+	-	+	0	0
+	+	+	+	0	0
-	+	-	-	0	0
-	+	-	+	0	0
-	+	+	+	0	0
+	-	-	+	63	8

EBV-CA-IgM	EBV-CA-IgG	EBV-EA-IgG	EBV-NA₁-IgG	B-ALL/例	T-ALL/例
-	-	-	-	7	5
+	+	-	-	3	4
+	+	-	+	0	0
+	+	+	+	0	0
-	+	-	-	0	0
-	+	-	+	0	0
-	+	+	+	0	0
+	-	-	+	63	8