Abstract:

Objective To investigate the clinical significance of plasma protein C（PC） activity and von Willebrand factor antigen（vWF：Ag） level in the treatment and prognosis of multiple myeloma（MM）. Methods Totally,81 patients who were diagnosed with MM were enrolled and classified into 3 groups according to international staging system（ISS）staging criteria（stage Ⅰ,Ⅱ and Ⅲ groups）. A total of 14 healthy subjects were enrolled as control group. PC activity and vWF：Ag level were determined and compared between MM and control groups. Results The levels of vWF：Ag in MM groups were higher than that in control group（P<0.05）. The level of vWF：Ag in males was higher than that in females（P<0.05）. The activities of PC in stage Ⅱ and stage Ⅲ were lower than that in control group（P<0.05）,and PC activity had a decreasing trend with disease progress. PC activity was decreased with ages（P<0.05）. The activity of PC was negatively correlated with ages in stage Ⅲ group（r=-0.361,P<0.05）. There was a positive correlation between PC activity and vWF：Ag level in stage Ⅲ group（r=0.363,P<0.05）. Conclusions PC and vWF：Ag would reflect the disease severity in some degree and are correlated,which play roles in the treatment and prognosis of patients with MM.

Key words: Von Willebrand factor, Protein C, Multiple myeloma