Abstract:

Objective To investigate the roles of peripheral blood inflammatory factors and coagulation indicators in endometriosis patients with pelvic adhesion. Methods A total of 58 endometriosis patients were enrolled as observation group,and 41 patients with benign ovarian cysts were enrolled as control group. According to the presence or absence of pelvic adhesion,the observation group was classified into pelvic adhesion group（47 cases） and non-pelvic adhesion group（11 cases）. The levels of peripheral blood inflammatory factors [tumor necrosis factor-alpha（TNF-α）,interleukin（IL）-6 and IL-8] and coagulation indicators [activated partial thromboplastin time（ATPP）,prothrombin time（PT）,platelet（PLT） and fibrinogen（Fib）] were determined. The correlation between inflammatory factors,coagulation indicators and pelvic adhesion was compared by Spearman correlation analysis. The roles of inflammatory factor and coagulation indicator single and combined determinations in pelvic adhesion were evaluated by receiver operating characteristic（ROC） curve. Results The levels of TNF-α,IL-6,IL-8 and Fib in observation group were higher than those in control group（P<0.05）,while PT was shorter than that in control group（P<0.05）. There was no statistical significance in APTT and PLT between observation and control groups（P>0.05）. The levels of TNF-α,IL-6,IL-8 and Fib in pelvic adhesion group were higher than those in non-pelvic adhesion group（P<0.05）,while PT was shorter than that in non-pelvic adhesion group（P<0.05）. There was no statistical significance in APTT and PLT between pelvic adhesion group and non-pelvic adhesion group（P>0.05）. TNF-α,IL-6,IL-8 and Fib were positively correlated with pelvic adhesion scores（r=0.679,0.524,0.645 and 0.655,P<0.05）,while PT was negatively correlated with pelvic adhesion（r=-0.598,P<0.001）. The areas under curves of TNF-α,IL-6,IL-8,PT and Fib and the combined determination were 0.785,0.830,0.807,0.734,0.662 and 0.983,respectively. Conclusions The combined determination of TNF-α,IL-6,IL-8,PT and Fib are closely related to the endometriosis and pelvic adhesion,which can be used as auxiliary diagnosis indicators for pelvic adhesion.

Key words: Endometriosis, Pelvic adhesion, Inflammatory factor, Coagulation indicator