Influence of red blood cell transfusion with radiation on serum inflammatory factors and prognosis of perioperative patients with esophageal carcinoma

doi:10.3969/j.issn.1673-8640.2017.04.011

Abstract

Abstract:

Objective To evaluate the influence of red blood cell transfusion with radiation on serum inflammatory factors and prognosis of perioperative patients with esophageal carcinoma. Methods A total of 159 patients with esophageal carcinoma were enrolled. All patients were randomly classified into radiation-free group （78 cases）and radiation group （81 cases）. The radiation-free group was given variant suspended red blood cell. The radiation group was given variant suspended red blood cell with radiation （¹³⁷Cs,25 Gy）. The levels of interleukin （IL）-6,IL-10,tumor necrosis factor alpha（TNF-α）and interferon gamma（IFN-γ）were determined before and after surgery in the 2 groups. The prognosis was evaluated. Results On the 1st and 7th days after surgery,the levels of IL-6 and IL-10 in radiation-free group were higher than those before surgery （P<0.05）,and were higher than those in corresponding radiation group （P<0.05）. On the 1st and 7th days after surgery,the level of IFN-γ in radiation-free group was lower than that before surgery （P<0.01）,and was lower than that in corresponding radiation group （P<0.01）. On the 1st day after surgery,the level of TNF-α in radiation-free group was lower than that before surgery （P<0.05）,and was lower than that in corresponding radiation group （P<0.05）. On the 1st and 7th days after surgery,the levels of indices mentioned above in radiation group had no statistical significance compared with those before surgery （P>0.05）. The days staying in hospital and in intensive care unit （ICU）had no statistical significance between the 2 groups （P>0.05）. For 1,3 and 5 years after surgery,the survival rates in radiation group were higher than those in radiation-free group （P<0.05）. Conclusions Compared with common blood transfusion,perioperative blood transfusion with radiation in patients with esophageal carcinoma has no immune suppression,and has a good prognosis. Giving the complexity for the influence of blood transfusion on prognosis,large clinical trials are still needed to confirm the conclusions based on the control of other factors.

Key words: Red blood cell transfusion with radiation, Inflammatory factors, Prognosis, Esophageal carcinoma

CLC Number:

R446.62

LIU Ye, ZHOU Ye, CHEN Bo, TANG Xiaofeng. Influence of red blood cell transfusion with radiation on serum inflammatory factors and prognosis of perioperative patients with esophageal carcinoma[J]. Laboratory Medicine, 2017, 32(4): 295-298.

Figures/Tables 2

References 15

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组别	例数	时间	IL-6	IL-10	TNF-α	IFN-γ
未辐照组	78	术前	35.93 ± 3.74	22.61 ± 2.73	24.33 ± 2.08	25.54 ± 2.41
		术后1 d	51.06 ± 2.85^**	29.45 ± 2.45^*	20.12 ± 2.15^*	12.28 ± 1.97^**
		术后7 d	73.62 ± 2.90^**	30.17 ± 2.11^*	24.11 ± 2.67	15.89 ± 1.99^**
辐照组	81	术前	36.21 ± 3.40	23.25 ± 2.49	25.95 ± 2.61	26.71 ± 2.70
		术后1 d	38.33 ± 4.16^##	24.21 ± 2.02^#	25.83 ± 2.57^#	29.31 ± 3.02^##
		术后7 d	36.58 ± 4.02^##	23.46 ± 1.83^#	24.77 ± 3.06	28.14 ± 2.91^##

组别	例数	时间	IL-6	IL-10	TNF-α	IFN-γ
未辐照组	78	术前	35.93 ± 3.74	22.61 ± 2.73	24.33 ± 2.08	25.54 ± 2.41
		术后1 d	51.06 ± 2.85^**	29.45 ± 2.45^*	20.12 ± 2.15^*	12.28 ± 1.97^**
		术后7 d	73.62 ± 2.90^**	30.17 ± 2.11^*	24.11 ± 2.67	15.89 ± 1.99^**
辐照组	81	术前	36.21 ± 3.40	23.25 ± 2.49	25.95 ± 2.61	26.71 ± 2.70
		术后1 d	38.33 ± 4.16^##	24.21 ± 2.02^#	25.83 ± 2.57^#	29.31 ± 3.02^##
		术后7 d	36.58 ± 4.02^##	23.46 ± 1.83^#	24.77 ± 3.06	28.14 ± 2.91^##

组别	例数	住院时间（d）	住ICU时间（d）	生存率（%）
组别	例数	住院时间（d）	住ICU时间（d）	1年	3年	5年
未辐照组	78	22.55 ± 4.72	1.52 ± 0.98	64.95	34.62	27.21
辐照组	81	19.83 ± 3.90	1.18 ± 0.69	78.29	49.16	41.72
统计值		0.204	-0.491	4.147	4.023	4.978
P值		0.849	0.649	0.042	0.045	0.026

组别	例数	住院时间（d）	住ICU时间（d）	生存率（%）
组别	例数	住院时间（d）	住ICU时间（d）	1年	3年	5年
未辐照组	78	22.55 ± 4.72	1.52 ± 0.98	64.95	34.62	27.21
辐照组	81	19.83 ± 3.90	1.18 ± 0.69	78.29	49.16	41.72
统计值		0.204	-0.491	4.147	4.023	4.978
P值		0.849	0.649	0.042	0.045	0.026