Correlation between serum thyroid hormones and Cr and Cys C in patients with initial thyroid dysfunction

doi:10.3969/j.issn.1673-8640.2020.07.014

Abstract

Abstract:

Objective To investigate the correlation between serum thyroid hormones and creatinine（Cr） and cystatin C（Cys C） in patients with initial thyroid dysfunction. Methods A total of 368 patients with thyroid dysfunction,including 108 cases of subclinical hypothyroidism,59 cases of hypothyroidism,102 cases of subclinical hyperthyroidism and 99 cases of hyperthyroidism,were enrolled. Totally,270 healthy subjects were enrolled as healthy control group. Serum thyroid-stimulating hormone（TSH）,free triiodothyronine（FT₃）,free thyroxine（FT₄）,Cr and Cys C levels were determined. Spearman correlation analysis was used to correlation evaluation. Results The level of serum Cr in hyperthyroidism group and serum Cys C levels in subclinical hypothyroidism group and hypothyroidism group were lower than those in healthy control group（P<0.01,P<0.05,P<0.01）. Serum Cys C level in hyperthyroidism group was higher than that in healthy control group（P<0.01）. Cr was negatively correlated with FT₃ and FT₄（r=-0.082 and -0.119,P<0.05）,and it was positively correlated with TSH（r=0.202,P<0.01）. Cys C was positively correlated with FT₃ and FT₄（r=0.281 and 0.197,P<0.01）,and it was negatively correlated with TSH（r=-0.214,P<0.01）. Conclusions Thyroid hormones in patients with thyroid dysfunction,especially in patients with hyperthyroidism,have effects on serum Cys C and Cr levels.

Key words: Creatinine, Cystatin C, Kidney function, Thyroid dysfunction

CLC Number:

R446.1

ZHANG Ke, TONG Shutao, ZHANG Detai. Correlation between serum thyroid hormones and Cr and Cys C in patients with initial thyroid dysfunction[J]. Laboratory Medicine, 2020, 35(7): 691-694.

Figures/Tables 2

References 13

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组别	例数	Cr/（μmol/L）	Cys C/（mg/L）
正常对照组	270	67.40±14.03	0.89（0.79~0.99）
亚临床甲减组	108	70.11±21.10	0.85（0.73~0.98）^*
甲减组	59	71.12±17.59	0.82（0.71~0.91）^**
亚临床甲亢组	102	65.98±22.62	0.90（0.77~1.00）
甲亢组	99	56.33±15.89^**	0.99（0.84~1.24）^**

组别	例数	Cr/（μmol/L）	Cys C/（mg/L）
正常对照组	270	67.40±14.03	0.89（0.79~0.99）
亚临床甲减组	108	70.11±21.10	0.85（0.73~0.98）^*
甲减组	59	71.12±17.59	0.82（0.71~0.91）^**
亚临床甲亢组	102	65.98±22.62	0.90（0.77~1.00）
甲亢组	99	56.33±15.89^**	0.99（0.84~1.24）^**

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