Abstract:

Objective To investigate the clinical application of neutrophil gelatinase-associated lipocalin（NGAL） in acute pancreatitis（AP）. Methods A total of 74 AP patients were enrolled,and there were 34 cases of mild acute pancreatitis（MAP） and 40 cases of severe acute pancreatitis（SAP）. A total of 20 healthy subjects were enrolled as healthy control group. Serum levels of NGAL,blood urea nitrogen（BUN）,creatinine（Cr）,C-reactive protein（CRP） and amylase（AMY） were determined. Using receiver operating characteristic（ROC） curve,the diagnostic performance of serum NGAL and AMY for AP was evaluated. Results Compared with SAP and MAP groups,serum NGAL,AMY and CRP levels were lower in healthy control group（P<0.05）,and NGAL and CRP levels in SAP group were higher than those in MAP group（P<0.05）. There was no statistical significance for AMY between the 2 groups（P>0.05）. BUN and Cr had no statistical significance among the 3 groups（P>0.05）. ROC curve analysis showed that the areas under curves（AUC） of NGAL and AMY for the diagnosis of AP were 0.722 and 0.784,the optimal cut-off values were 240 ng/mL and 250 U/L,the sensitivities were 90.0% and 83.3%,and the specificities were 55.4% and 63.9%,respectively. Conclusions Serum NGAL determination plays a role in the diagnosis of AP,which can reflect the degree of AP infection.

Key words: Neurtrophil gelatinase-associated lipocalin, Amylase, Acute pancreatitis