Research status of decolonization strategy of carbapenem-resistant Enterobacteriaceae

doi:10.3969/j.issn.1673-8640.2020.10.003

Abstract

Abstract:

The treatment options of multi-drug resistance bacterial infection are limited,and are often inefficient,especially for carbapenem-resistant Enterobacteriaceae（CRE）. The colonization of CRE will increase the risk of CRE infection,and the clinical mortality will increase. This review summarizes the epidemiological characteristics of CRE,the hazard of colonization and the existing prevention and control measures,which discusses the feasibility and effectiveness of 2 decolonization strategies,including selective digestive decontamination（SDD） and fecal bacterium transplantation（FMT）,which have attracted international attention recently. This review also enumerates the advantages and disadvantages of the 2 methods of decolonization and the problems that need to be solved in the future. Although there is little research evidence on the effectiveness of FMT to decolonize CRE,it is none the less a reliable choice for CRE decolonization.

Key words: Carbapene resistant Enterobacteriaceae, Decolonization, Selective digestive decontamination, Fecal bacterium transplantation

CLC Number:

R446.5

ZOU Chengyun, YANG Hongmei, WANG Haiying. Research status of decolonization strategy of carbapenem-resistant Enterobacteriaceae[J]. Laboratory Medicine, 2020, 35(10): 974-978.

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