Abstract:

Objective To analyze the drug resistance and molecular epidemiology of Staphylococcus aureus with suppurative infection in the first half of 2017,and to provide a reference for the rational use of antibiotics. Methods The clinical isolates of Staphylococcus aureus with suppurative infection were collected from January to June,2017. Identification and drug susceptibility test were performed by Vitek 2 Compact automatic microbial identification system. The molecular epidemiology of Staphylococcus aureus was analyzed by spa typing and multilocus sequence typing（MLST）. Results A total of 171 isolates ofStaphylococcus aureus were isolated. There were 113 isolates from community infection and 58 isolates from nosocomial infection. The methicillin-resistant Staphylococcus aureus（MRSA） isolation rate in nosocomial infection group was 62.07%,which was higher than that in community infection group（30.97%）. The results of molecular typing showed that the main types in nosocomial and community infection groups were ST239-t030 and ST239-t037,respectively. Conclusions At Xijing Hospital in the first half of 2017,there are differences for Staphylococcus aureus between nosocomial and community infection groups. MRSA clones are relatively concentrated,and nosocomial infection group has spread phenomenon. The control of nosocomial infection should be strengthened,in order to reduce the incidence of nosocomial infection.

Key words: Suppurative infection, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, Multilocus sequence typing, Spa typing, Drug resistance