Relations of MTHFR gene C677T polymorphism with hyperhomocysteinemia and acute coronary syndrome

doi:10.3969/j.issn.1673-8640.2017.011.016

Abstract

Abstract:

Objective To investigate the relations of methylenetetrahydrofolate reductase（MTHFR） gene C677T polymorphism with hyperhomocysteinemia（HHcy） and acute coronary syndrome（ACS）. Methods A total of 81 patients with ACS,including 51 cases of normal homocysteine（Hcy） and 30 cases of HHcy,and 98 healthy subjects（healthy control group） were enrolled. The relations of MTHFR gene C677T polymorphism with HHcy and ACS susceptibility were analyzed. Results The distribution of genotypes in ACS group and healthy control group was in conformity with the principle of Hardy-Weinberg equilibrium. Compared to healthy control group,the odds ratios（OR） [95% confidence interval（CI）] for ACS of MTHFR gene C677T TT to CC,TT to CT+CC and T to C were 2.60（1.12-6.03）,2.02（1.06-3.86） and 1.66（1.09-2.53）,respectively. Furthermore,the OR（95%CI）for HHcy of MTHFR gene C677T TT to CT+CC was 2.74（1.08-7.00）. Conclusions MTHFR gene C677T TT genotype is a risk factor for HHcy and may increase the risk of ACS.

Key words: Methylenetetrahydrofolate reductase, Gene polymorphism, Acute coronary syndrome, Hyperhomocysteinemia

CLC Number:

R446.1

YUAN Yongming, ZHANG Xiaoying, GU Xidong, ZHANG Jue, HAN Qian. Relations of MTHFR gene C677T polymorphism with hyperhomocysteinemia and acute coronary syndrome[J]. Laboratory Medicine, 2017, 32(11): 1013-1016.

Figures/Tables 2

References 9

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组别	例数	基因型			等位基因
组别	例数	CC	CT	TT	T	C
ACS组	81	14（17.28）	36（44.44）	31（38.27）	98（60.49）	64（39.51）
HHcy组	30	6（20.00）	8（26.67）	16（53.33）^*	40（66.67）	20（33.33）
正常Hcy组	51	8（15.69）	28（54.90）	15（29.41）	58（56.86）	44（43.14）
正常对照组	98	27（27.55）	48（48.98）	23（23.47）	94（47.96）	102（52.04）

组别	例数	基因型			等位基因
组别	例数	CC	CT	TT	T	C
ACS组	81	14（17.28）	36（44.44）	31（38.27）	98（60.49）	64（39.51）
HHcy组	30	6（20.00）	8（26.67）	16（53.33）^*	40（66.67）	20（33.33）
正常Hcy组	51	8（15.69）	28（54.90）	15（29.41）	58（56.86）	44（43.14）
正常对照组	98	27（27.55）	48（48.98）	23（23.47）	94（47.96）	102（52.04）

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