Research progress of Prototheca

doi:10.3969/j.issn.1673-8640.2017.010.021

Abstract

Abstract:

Prototheca is a kind of opportunistic pathogen which exists widely in nature. The clinical symptom of animal infection is mastitis,while human protothecosis is always classified to 3 forms,cutaneous lesions,olecranon bursitis and systemic infections. Currently,clinical medicine still regards morphological observation and biochemical tests as main determination methods. However,these methods are always effected by time-consuming,subjective influence and the lack of understanding in China,which results in low determination rate. For improving the knowledge of Prototheca,the biological characteristics,pathogenicity,epidemiology,identification,clinical symptoms and drug resistance of Prototheca are reviewed.

Key words: Prototheca, Protothecosis, Endospore, Opportunistic pathogen, Identification, Genotype

CLC Number:

R446.1

ZHAO Yue, ZHU Weiwei, LIU Jinyan, LI Wenjing, WANG Ying, SHI Ce, XIANG Mingjie. Research progress of Prototheca[J]. Laboratory Medicine, 2017, 32(10): 928-932.

References 36

[1]	KOVALYSHYN I,BRANKOV N,FERNANDEZ A P.Erythematous and edematous plaques on the bilateral extremities in an immunocompromised patient. Protothecosis[J]. Int J Dermatol,2016,55(2):e59-e61.
[2]	YEH C T,LI M C,CHUANG Y C,et al.Prototheca algaemia:a rare but fatal opportunistic infection among immunocompromised individuals[J]. Jpn J Infect Dis,2013,66(6):523-525.
[3]	RICCHI M,DE CICCO C,BUZZINI,et al. First outbreak of bovine mastitis caused by Prototheca blashkeae[J]. Vet Microbiol,2013,162(2-4):997-999.
[4]	TAKANO M,HOSHI S,NAGAI K,et al.The first case of human protothecosis caused by Prototheca zopfii in Japan[J]. J Infect Chemother,2014,20(10):647-649.
[5]	SATOH K,OOE K,NAGAYAMA H,et al.Prototheca cutis sp.nov.,a newly discovered pathogen of protothecosis isolated from inflamed human skin[J]. Int J Syst Evol Microbiol,2010,60(Pt 5):1236-1240.
[6]	TAKANO M,HOSHI S,NAGAI K,et al.The first case of human protothecosis caused by Prototheca zopfii in Japan[J]. J Infect Chemother,2014,20(10):647-649.
[7]	MARQUES S,SILVA E,CARVALHEIRA J,et al.Phenotypic characterization of mastitic Prototheca spp. isolates[J]. Res Vet Sci,2010,89(1):5-9.
[8]	LASS-FLORL,MAYR A.Human protothecosis[J].Clin Microbiol Rev,2007,20(2):230-242.
[9]	BANDARANAYAKE T D,PANIZ MONDOLFI A,PEAPER D R,et al.Prototheca wickerhamii algaemia:an emerging infection in solid organ transplant recipients[J]. Transpl Infect Dis,2015,17(4):599-604.
[10]	Protothecosis:a lethal infection due to an achlorophylous algae[J]. Clin Infect Dis,2014,59(12):iv.
[11]	MACESIC N,FLEMING S,KIDD S,et al.Protothecosis in hematopoietic stem cell transplantation:case report and review of previous cases[J]. Transpl Infect Dis,2014,16(3):490-495.
[12]	FIGUEROA C J,CAMP B J,VARGHESE G I,et al.A case of protothecosis in a patient with multiple myeloma[J]. J Cutan Pathol,2014,41(5):409-413.
[13]	TODD JR,KING JW,OBERLE A,et al.Protothecosis:report of a case with 20-year follow-up,and review of previously published cases[J]. Med Mycol,2012,50(7):673-689.
[14]	康俞莉,章强强. 无绿藻的研究进展:从基础到临床[J]. 中国真菌学杂志,2012,7(4):242-246.
[15]	HUTH N,WENKEL R F,ROSCHANSKI N,et al.Prototheca zopfii genotype 2-induced nasal dermatitis in a cat[J]. J Comp Pathol,2015,152(4):287-290.
[16]	FONT C,MASCORT J,MÁRQUEZ M,et al. Paraparesis as initial manifestation of a Prototheca zopfii infection in a dog[J]. J Small Anim Pract,2014,55(5):283-286.
[17]	MANINO P M,OLIVEIRA F,FICKEN M,et al.Disseminated protothecosis associated with diskospondylitis in a dog[J]. J Am Anim Hosp Assoc,2014,50(6):429-435.
[18]	CHOU D W,CHUNG K M,LEE C T.Prototheca wickerhamii cutaneous and systemic infections[J]. Am J Trop Med Hyg,2014,91(4):664-665.
[19]	KANO R,SOBUKAWA H,SUZUKI M,et al.Immunohistopathology of Prototheca wickerhamii in cutaneous lesions of protothecosis[J]. Med Mycol J,2014,55(1):E29-E32.
[20]	TELLO-ZAVALA M C,MERCADO-LARA A,GÓMEZ-HERNÁNDEZ N,et al. Disseminated protothecosis in a Mexican child[J]. Pediatr Infect Dis J,2013,32(12):e476-e477.
[21]	GANDHAM N R,VYAWAHARE C R,CHAUDHAURY N,et al.Onychoprotothecosis:an uncommon presentation of protothecosis[J]. Indian J Med Microbiol,2015,33(3):435-437.
[22]	ZHANG Q,LI L,YULI K,et al.A case of cutaneous protothecosis mimics eczema[J]. Mycopathologia,2015,179(1-2):163-166.
[23]	HIROSE N,NISHIMURA K,INOUE-SAKAMOTO M,et al.Ribosomal internal transcribed spacer of Prototheca wickerhamii has characteristic structure useful for identification and genotyping[J]. PLoS One,2013,8(11):e81223.
[24]	MARQUES S,HUSS V A,PFISTERER K,et al.Internal transcribed spacer sequence-based rapid molecular identific ation of Prototheca zopfii and Prototheca blaschkeae directly from milk of infected cows[J]. J Dairy Sci,2015,98(5):3001-3009.
[25]	SOBUKAWA H,IBARAKI M,KANO R,et al.Rapid molecular typing of Prototheca zopfii by high resolution melting real-time PCR(PCR-HRM)[J]. Med Mycol J,2013,54(4):341-344.
[26]	RICCHI M,CAMMI G,GARBARINO C A,et al.A rapid real-time PCR/DNA resolution melting method to identify Prototheca species[J]. J Appl Microbiol,2011,110(1):27-34.
[27]	CREMONESI P,POZZI F,RICCHI M,et al.Technical note:identification of Prototheca species from bovine milk samples by PCR-single strand conformation polymorphism[J]. J Dairy Sci,2012,95(12):6963-6968.
[28]	CAPRA E,CREMONESI P,CORTMIGLIA C,et al.Simultaneous identification by multiplex PCR of major Prototheca spp. isolated from bovine and buffalo intramammary infection and bulk tank[J]. Lett Appl Microbiol,2014,59(6):642-647.
[29]	WANG X,FU Y F,WANG R Y,et al.Identification of clinically relevant fungi and Prototheca species by rRNA gene sequencing and multilocus PCR coupled with electrospray ionization mass spectrometry[J]. PLoS One,2014,9(5):e98110.
[30]	MURUGAIYAN J,AHRHOLDT J,KOWBEL V,et al.Establishment of a matrix-assisted laser desorption ionization time-of-flight mass spectrometry database for rapid identification of infectious achlorophyllous green micro-algae of the genus Prototheca[J]. Clin Microbiol Infect,2012,18(5):461-467.
[31]	JAGIELSKI T,BUZZINI P,LASSA H,et al.Multicentre Etest evaluation of in vitro activity of conventional antifungal drugs against European bovine mastitis Prototheca spp. isolates[J]. J Antimicrob Chemother,2012,67(8):1945-1947.
[32]	MURATA M,ITO T,NAGAE K,et al.Disseminated protothecosis manifesting with multiple,rapidly-progressing skin ulcers:successful treatment with amphotericin B[J]. Eur J Dermatol,2015,25(2):208-209.
[33]	KNOX J,COLOE S V,PERERA C,et al.Prototheca wickerhamii olecranon bursitis successfully treated with adjunctive systemic itraconazole[J]. Pathology,2015,47(4):388-391.
[34]	FARRAG H A,A-KARAM EI-DIN A,MOHAMED EI-SAYED Z G,et al. Microbial colonization of irradiated pathogenic yeast to catheter surfaces:relationship between adherence,cell surface hydrophobicity,biofilm formation and antifungal susceptibility. A scanning electron microscope analysis[J]. Int J Radiat Biol,2015,91(6):519-527.
[35]	KWIECINSKI J.Biofilm formation by pathogenic Prototheca algae[J]. Lett Appl Microbiol,2015,61(6):511-517.
[36]	MORANDI S,CREMONESI P,CAPRA E,et al.Molecular typing and differences in biofilm formation and antibiotic susceptibilities among Prototheca strains isolated in Italy and Brazil[J]. J Dairy Sci,2016,99(8):6436-6445.