The variation and significance of IL-17 and IL-23 in adult patients with primary nephrotic syndrome

doi:10.3969/j.issn.1673-8640.2015.05.002

Abstract

Abstract:

Objective　To investigate the changes of interleukin 17 (IL-17) and interleukin 23 (IL-23) in adult patients with primary nephrotic syndrome (PNS) and their roles and clinical significance of IL-17 and IL-23 variations in the occurrence and development of PNS. Methods　A total of 35 steroid-effective hospitalized patients with PNS and 20 healthy subjects (healthy control group) were enrolled in the study. The patients with PNS were treated with prednisone according to the conventional dose. T cell subsets from peripheral blood and the levels of IL-17,IL-23 and IL-6 from serum and 24 h urine were detected in healthy control group and the patients with PNS before and after treatment. The correlations of 24 h urinary protein quantification with T cell subsets in peripheral blood and the levels of IL-17,IL-23 and IL-6 in both serum and 24 h urine were analyzed,respectively. Results　Compared with healthy control group, the percentage of CD3⁺ or CD3⁺CD4⁺ cells from patients with PNS significantly decreased (P<0.05), and the levels of IL-17 and IL-6 from serum as well as IL-17, IL-23 and IL-6 from 24 h urine significantly increased(P<0.05). After treatment, the percentage of CD3⁺ or CD3⁺CD4⁺ cells significantly increased (P<0.05), and the levels of IL-17, IL-23 and IL-6 in 24 h urine significantly decreased (P<0.05). There were positive correlations between 24 h urinary protein quantification and the levels of IL-17 and IL-23 in both serum and 24 h urine respectively (P<0.01). Conclusions　IL-17 and IL-23 may contribute to the proteinuria of PNS. Hormone therapy can improve the disorder of cell immune function and the imbalance of T cell subsets. Monitoring the levels of IL-17 and IL-23 in serum and 24 h urine may be helpful for disease judgement and clinical therapy.

Key words: Interleukin 17, Interleukin 23, Interleukin 6, T cell subset, 24 h urinary protein quantification, Primary nephrotic syndrome

CLC Number:

R446.62

ZHOU Yunjiao, ZHANG Lihong, LI Peng, YE Xianwu, NIU Jianying. The variation and significance of IL-17 and IL-23 in adult patients with primary nephrotic syndrome[J]. , 2015, 30(6): 554-558.

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