The research progress on long non-coding RNA in immune inflammatory reaction

doi:10.3969/j.issn.1673-8640.2015.10.019

Abstract

Abstract:

As a new field of regulatory genes in genome research, long non-coding RNA(lncRNA)plays an important role in each stage of cell biological activity, including mediating chromatin remodeling, mRNA alternative splicing, mRNA degradation and protein translation, with complex biological functions. Up to now, a variety of lncRNA have been found in cancers, cardiovascular diseases and neurodegenerative diseases, however, the research of lncRNA in immune system is still limited. Recent studies have found that lncRNA can interact with protein compounds or transcription factors, then regulate the differentiation of immune cells, and regulate the expression of inflammatory cytokines in order to control the inflammatory response. At present, in some immune diseases, several lncRNA expresses with differences, but the exact mechanisms remain to be seen. Therefore, this review mainly outlines the significant functions of lncRNA in the regulation of immune cell differentiation and immune inflammatory regulation in brief.

Key words: Long non-coding RNA, Transcription regulation, Immune cell, Immune inflammtory response

CLC Number:

Q503

WEI Tingting, YANG Min, TANG Qingqin, ZHONG Renqian.. The research progress on long non-coding RNA in immune inflammatory reaction[J]. Laboratory Medicine, 2015, 30(10): 1044-1047.

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