Abstract: Objective To investigate the distribution and drug resistance of pathogenic fungi causing vulvovaginal candidiasis(VVC) in infertility women, and provide the reference for clinical treatment. Methods The CHROMagar Candida color medium was applied to identify Candida isolated from the vaginal secretions collected from infertility women, and Rosco disc diffusion method was used for drug susceptibility.Results A total of 86 Candida isolates were isolated from 454 vaginal secretion samples, including 48 isolates of Candida albicans(55.81%), 24 isolates of Candida glabrata(27.91%), 8 isolates of Candida tropicalis (9.30%), 4 isolates of Candida krusei (4.65%) and 2 isolates of Candida parapsilosis (2.33%). The sensitivity rates of Candida isolates to amphotericin B, ketoconazole, miconazole, fluconazole and itraconazole were 93.55%, 77.91%, 65.12%, 62.79% and 59.30% respectively. Conclusions The non-Candida albicans infection in infertility women with VVC increases obviously, and the drug sensitivities of different types of Candida isolates are different. Therefore, antibiotic drugs should be carefully used being based on the results of fungal culture identification and drug sensitivity test.

Key words: Candida, Drug sensitivity test, Infertility, Woman