The application significance of serum insulin-like growth factor 1 determination in the early diagnosis of non-small cell lung cancer

doi:10.3969/j.issn.1673-8640.2013.05.012

Abstract

Abstract: Objective　To study the sigificance of insulin-like growth factor 1（IGF-1）in the diagnosis of non-small cell lung cancer. Methods　The serum IGF-1 levels in 90 patients with non-small cell lung cancer and 20 healthy controls were determined by immunoradiometric quantitation assay. Results　The levels of serum IGF-1 were significantly higher in non-small cell lung cancer group than in healthy control group [（122.6±20.3）ng/mL and（82.7±20.5）ng/mL，P＜0.05]. The levels of IGF-1 in all patients with lymphatic metastasis [（133.2±21.3）ng/mL] were higher than those in patients without lymphatic metastasis [（108.2±15.1）ng/mL，P＜0.05]. The levels of IGF-1 in patients at Phase Ⅲ-Ⅳ[（129.3±20.1）ng/mL] were higher than those at Phase Ⅰ-Ⅱ [（115.2±15.2）ng/mL，P＜0.05]. In non-small cell lung cancer group，the levels of IGF-1 had a significantly positive correlation with carcinoembryonic antigen（CEA）and cytokeratin-19-fragment（CYERA21-1）respectively（r＝0.58 and r＝0.49，P＜0.01）. Conclusions　High level of serum IGF-1 may have a significant correlation with the pathogenesis，development and metastasis of non-small cell lung cancer，and IGF-1 may have an application significance for the early diagnosis of lung cancer.

Key words: Insulin-like growth factor 1, Non-small cell lung cancer, Early diagnosis

SHI Yue 1，ZHANG Jun 2，CHEN Peng 3.. The application significance of serum insulin-like growth factor 1 determination in the early diagnosis of non-small cell lung cancer[J]. , 2013, 28(6): 503-505.

References

[1]Velcheti V，Govindan R. Insulin-like growth factor and lung cancer [J]. J Thorac Oncol，2006，1（7）: 607-610.
[2]Grimberg A，Cohen P. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis [J]. J Cell Physiol，2000，183（1）: 1-9.
[3]刘宏景，李沛，刘惠敏，等. 血清胰岛素样生长因子1水平与肝病关系的研究[J]. 检验医学，2005，20（2）:95-97.
[4]Wu Y，Cui K，Miyoshi K，et al. Reduced circulating insulin-like growth factorⅠ levels delay the onset of chemically and genetically induced mammary tumors[J]. Cancer Res，2003，63（15）: 4384-4388.
[5]Qi HW，Shen Z，Fan LH. Combined inhibition of insulin-like growth factor-1 receptor enhances the effects of gefitinib in a human non-small cell lung cancer resistant cell line[J]. Exp Ther Med，2011，2（6）: 1091-1095.
[6]徐平，皮佳俐，刘媛媛，等. IGF-1和IGFBP-3在肺癌患者血清中的表达及临床意义[J]. 湖南师范大学学报（医学版），2007，4（1）: 11-14.
[7]Fürstenberger G，Senn HJ. Insulin-like growth factors and cancer[J]. Lancet Oncol，2002，3（5）:298-302.
[8]Izycki T，Chyczewska E，Naumnik W，et al. Serum levels of IGF-1 and IGFBP-3 in patients with lung cancer during chemotherapy [J]. Oncol Res，2006，16（1）: 49-54.
[9]Weroha SJ，Haluska P.The insulin-like growth factor system in cancer[J]. Endocrinol Metab Clin North Am，2012，41（2）:335-350.
[10]盛辉，苑春莉，王医术. 胰岛素样生长因子-1及其受体在肺癌中的表达 [J]. 江苏医药，2006，32（9）:818-820.
[11]Knowlden JM，Jones HE，Barrow D，et al.Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling: implication for Gefitinib（〖JP20〗′Iressa′）response and resistance[J]. Breast Cancer Res Treat，2008，111（1）: 79-91.

[1]	ZHOU Yunlan, SHEN Lisong. Clinical application and challenges of liquid biopsy biomarkers in non-small cell lung cancer [J]. Laboratory Medicine, 2023, 38(9): 807-811.
[2]	CHEN Ying, LI Wei, LIN Tao, YANG Li. Relationship between PFTK1 expression level and microvessel density and postoperative prognosis in non-small cell lung cancer [J]. Laboratory Medicine, 2023, 38(7): 634-639.
[3]	YANG Zhongxin, LI Xiaoyu, CHEN Tao, CAO Wenjun. Roles of IL-8 and MMP-2 in the prognosis of non-small cell lung cancer patients after thoracoscopic segmentectomy [J]. Laboratory Medicine, 2023, 38(4): 342-346.
[4]	SONG Shiwei, LI Jingwu, LIN Tao, LIU Zeyu, WANG Zhiqiang, SUN Weidong. Relationship between GPNMB and non-small cell lung cancer immune infiltration and prognosis [J]. Laboratory Medicine, 2023, 38(4): 347-351.
[5]	ZHAO Mingna, ZHANG Chenzi, HONG Qiushuang, LOU Jiatao. Mechanism of IL-8/miR-182 positive feedback regulatory axis in non-small cell lung cancer [J]. Laboratory Medicine, 2022, 37(4): 349-355.
[6]	XU Runhao, ZOU Chen, CAO Yun, CHEN Feng, LIU Yijing, ZHANG Shulin, ZHANG Jie. Roles of serum amino acid determinations in the diagnosis of early non-small-cell lung cancer [J]. Laboratory Medicine, 2022, 37(12): 1157-1163.
[7]	ZHAO Ying, Gasongzhuoga, Cibai, LIU Zhijuan, XU Yingchun. Application of Xpert MTB/RIF in tuberculosis diagnosis in high altitude localities [J]. Laboratory Medicine, 2021, 36(9): 947-950.
[8]	PENG Jiaowu, SUN Chengmou. Diagnostic value of miR-124a and miR-449a in plasma of non-small cell lung cancer [J]. Laboratory Medicine, 2021, 36(1): 34-38.
[9]	WANG Zijin, ZHANG Xiaoying. Role of apolipoprotein M in the proliferation,migration and invasion of non-small cell lung cancer A549 cells [J]. Laboratory Medicine, 2020, 35(9): 937-942.
[10]	YUAN Shiyang, LIU Chuan, OUYANG Xiaochun, XIE Junping, HE Rongzhi, LI Lixiang, ZOU Yeqing. Clinical significance of detecting plasma EGFR T790M gene mutation in patients with NSCLC by 3D digital PCR [J]. Laboratory Medicine, 2020, 35(8): 806-810.
[11]	CAO Jijun, WANG Jinhu, SHEN Xianjuan, JU Shaoqing. Expression and clinical significance of long noncoding RNA CCAT2 in serum of patients with gastric cancer [J]. Laboratory Medicine, 2019, 34(9): 775-779.
[12]	GAO Feng. Research improvement of the basis and transformation of tumor markers in clinical laboratories [J]. Laboratory Medicine, 2019, 34(2): 95-97.
[13]	FU Xiaoling, CHEN Kun, XU Jiaxue, GUAN Ming. Clinical characteristic of cerebrospinal fluid for non-small cell lung cancer patients with leptomeningeal metastasis [J]. Laboratory Medicine, 2018, 33(8): 692-696.
[14]	LU Wenfeng, ZHANG Jie, FANG Chengzhi. Several indicators for the early diagnosis of neonatal severe infection [J]. Laboratory Medicine, 2018, 33(7): 612-615.
[15]	KONG Changsheng, CHEN Jun, QI Qiaoli, ZHU Lingna, ZHANG Yi, ZOU Xiaoyan. Significance on smear Gram staining microscopy of sputum through nose sampling among children for the early diagnosis of community-acquired pneumonia [J]. Laboratory Medicine, 2016, 31(3): 201-204.