A meta analysis on the diagnosis significance of anti-alpha-fodrin antibodies for Sj gren′s syndrome

Abstract

Abstract: Objective　To investigate the diagnosis significance of anti-alpha-fodrin antibodies for Sjgren′s syndrome（SS）. Methods　After a systematic review of literatures，the sensitivity，specificity，positive and negative likelihood ratios（PLR/NLR） and diagnosis advantage ratio（DOR） of anti-alpha-fodrin antibodies by enzyme-linked immunosorbent assay（ELISA） in the diagnosis of SS defined by international 2002 criteria were pooled by random-effect models. Summary receiver operating characteristic（sROC） curves were used to summarize the overall determination performance. Results　Seven studies met the criteria. The summary evaluations for anti-alpha-fodrin antibody IgA and IgG in the diagnosis of SS were as follows：sensitivities 0.30 [95% confidence interval（CI） 0.25-0.34] and 0.32（95% CI 0.28-0.36）；specificities 0.90（95%CI 0.87-0.93） and 0.83（95% CI 0.80-0.86），respectively. The designed studies were with low quality，and the significant heterogeneity was observed. Conclusions　Anti-alpha-fodrin antibodies have poor sensitivity and high specificity for the diagnosis of SS. The explanation for anti-alpha-fodrin antibody determination result should be based on clinicalfeatures.

Key words: Anti-alpha-fodrin antibody, Sj gren′s syndrome, Meta analysis

QIN Qin 1，SUN Yi 1，GU Mingli 1，HU Zhide 2，CHEN Sunxiao 3，DENG Anmei 1. A meta analysis on the diagnosis significance of anti-alpha-fodrin antibodies for Sj gren′s syndrome[J]. , 2012, 27(12): 1074-1079.

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