Abstract:

Objective To evaluate the role of pleural effusion interferon-gamma release assay（IGRA） for the diagnosis of tuberculous pleural effusion. Methods Databases included PubMed,EMbase,Medline,the Cochrane Library（Issue 6,2015）,CNKI,WanFang Data and VIP,and related literature was searched from inception to July 1st,2016. Two reviewers screened literature according to the inclusion and exclusion criteria,extracted related data and assessed. Meta-Disc 1.4 software was used to perform Meta analysis. Pooled sensitivity,pooled specificity,pooled positive likelihood ratio,pooled negative likelihood ratio,pooled diagnostic odds ratio and area under curve（AUC） of summary receiver operating characteristic（SROC）curve was used to assess the diagnosis efficiency. Results A total of 27 studies involving 2 072 patients with pleural effusion were included. The pooled sensitivity,pooled specificity,pooled positive likelihood ratio,pooled negative likelihood ratio,pooled diagnostic odds ratio and the AUC of SROC curve were 0.85 [95% confidence interval（CI）0.83-0.87],0.85（95% CI 0.83-0.88）,5.37（95% CI 3.38-8.53）,0.16（95% CI 0.09-0.26） and 41.31（95% CI 17.48-97.61） and 0.930 0,respectively. Conclusions Pleural effusion IGRA plays a role for the diagnosis of tuberculous pleural effusion.

Key words: Interferon-gamma release assay, Tuberculosis, Pleural effusion, Meta analysis