Diagnosis value of Xpert MTB/RIF assay for different types of lymph node tuberculosis

doi:10.3969/j.issn.1673-8640.2021.09.011

Abstract

Abstract:

Objective To investigate the diagnostic value of Xpert MTB/RIF assay for different types of lymph node tuberculosis. Methods Xpert MTB/RIF assay was used to determine 235 patients with different types of lymph node tuberculosis and 81 patients with non-tuberculosis lymphadenopathy（control group）,and the positive determination rates were compared with those of acid-fasting staining and gamma-interferon release assay（IGRA）. The efficiency of Xpert MTB/RIF assay in the diagnosis of different types of lymph node tuberculosis was analyzed. Results Compared with control group（the positive determination rate was 0）,the positive determination rate of Xpert MTB/RIF assay in patients with lymph node tuberculosis was higher（the positive determination rate was 84.7%）（P<0.001）. The sensitivity of Xpert MTB/RIF assay（84.7%） was higher than that of acid-fasting staining（7.7%,P<0.001）,but it was lower than that of IGRA（91.5%,P<0.001）. The specificity was consistent with that of acid-fasting staining（100%）,and it was higher than that of IGRA（80.2%,P<0.001）. The positive determination rate of Xpert MTB/RIF assay in axillary lymph node tuberculosis was the highest（90.2%）,and there was no statistical significance for different types of lymph node tuberculosis（P>0.05）. The positive determination rates of Xpert MTB/RIF assay were 91.7%,78.0% and 84.8% in the 3 pathologic types of lymph node tuberculosis with caseous type,proliferative type and mixed type,respectively（P>0.05）. Conclusions Xpert MTB/RIF assay is a method with high sensitivity,good specificity and low biohazard,which can be used for the rapid diagnosis of different types of lymph node tuberculosis.

Key words: Xpert MTB/RIF assay, Tuberculosis, Lymph node, Tuberculosis disease

CLC Number:

R446.1

ZHANG Guoying, HE Fang, XIA Xia, GUO Yidi, XU Weiping, HUANG Zihui. Diagnosis value of Xpert MTB/RIF assay for different types of lymph node tuberculosis[J]. Laboratory Medicine, 2021, 36(9): 935-938.

Figures/Tables 1

References 14

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检测方法	敏感性	特异性	阳性预测值	阴性预测值
Xpert MTB/RIF	84.7（199/235）	100.0（81/81）	100.0（199/199）	69.2（81/117）
IGRA	91.5（215/235）^*	80.2（65/81）^*	93.1（215/231）	80.2（81/101）
抗酸染色	7.7（18/235）^*	100.0（81/81）	100.0（18/18）	27.2（81/298）

检测方法	敏感性	特异性	阳性预测值	阴性预测值
Xpert MTB/RIF	84.7（199/235）	100.0（81/81）	100.0（199/199）	69.2（81/117）
IGRA	91.5（215/235）^*	80.2（65/81）^*	93.1（215/231）	80.2（81/101）
抗酸染色	7.7（18/235）^*	100.0（81/81）	100.0（18/18）	27.2（81/298）

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