Abstract: Objective To use Meta analysis to evaluate the risk factors of diabetic foot in China. Methods The following databases such as China National Knowledge Infrastructure (CNKI), Chinese Weipu Database, Pubmed,EMbase, Chinese Biological Medicine Database(CBM),WANFANG Database and handsearched relevant literature were searched to collect case-control studies on the related risk factors of diabetic foot in China.The retrieval time reached from inception to December, 2013. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data and assessed the quality.The Meta analysis was performed by RevMan5.0 software. The various risk factors were analyzed by fixed effect model or random effect model pooled odds ratio(OR)and 95% confidence interval (CI), with stability evaluated by sensitivity analysis.Moreover, the funnel plot was used to assess the published bias of articles. Results A total of 15 articles were included, the key risk factors such as age(OR=7.51, 95%CI: 6.74-8.28), course of disease(OR=3.34, 95%CI: 2.96-3.72), body mass index(BMI)(OR=-0.53, 95%CI:-0.80-0.26), systolic blood pressure(OR=9.84, 95%CI: 8.08-11.60), diastolic blood pressure(OR=1.03, 95%CI: 0.03-2.03), fasting blood glucose(FPG)(OR=1.48, 95%CI: 1.19-1.77), 2 h post prandial blood glucose(2 hPG)(OR=2.15, 95% CI: 1.71-2.59), glycosylated hemoglobin A_1c(HbA_1c)(OR=1.46, 95%CI: 1.03-1.88), total cholesterol(TC)(OR=-0.31, 95%CI: -0.42-0.19) and high-density lipoprotein-cholesterol(HDL-C)(OR=-0.07, 95%CI: -0.10-0.03) (P<0.01)affected the happening of diabetic foot, but triglyceride (TG) (OR=-0.06, 95%CI: -0.16-0.04), low-density lipoprotein-cholesterol(LDL-C)(OR=-0.05, 95%CI: -0.21-0.11)did not statistically influence on diabetic foot(P>0.05). Conclusions Age, course of disease, BMI, systolic blood pressure, diastolic blood pressure, FPG, 2 hPG, HbA_1c, TC and HDL-C are primarily determined as the important risk factors of diabetic foot, which can provide the reference for the early prevention of diabetic foot occurred in clinic.

Key words: Diabetic foot, Risk factor, Meta analysis