Abstract:

Objective To investigate the characteristics of leukocyte morphological parameters（LMP） in diagnosing influenza A and B. Methods A total of 77 patients with influenza A,109 patients with influenza B and 101 healthy subjects were enrolled in Shanghai Jiao Tong University School of Medicine Ruijin Hospital from July 2019 to January 2020 and were determined for blood routine test,C-reactive protein（CRP）,influenza A virus and influenza B virus. Results There were 28 CRP-positive patients and 49 CRP-negative patients in influenza A group. There were 23 CRP-positive patients and 85 CRP-negative patients in influenza B group. CRP and influenza A and B viruses were negative in healthy control group. In patients with influenza A and influenza B and healthy subjects with negative CRP results,the percentage of neutrophil（NEUT%）,the percentage of monocyte（MO%）,monocyte forward scattered light central position（Mon_FSC_CenterPos）,monocyte forward scattered light distribution width（Mon_FSC_Width） and high fluorescence intensity cell percentage（HFC%） had statistical significance among the 3 groups（P<0.01）. Among CRP-positive patients with influenza A and B,HFC% and Mon_FSC_CenterPos had statistical significance in influenza A and B groups（P<0.05）. Conclusions Mon_FSC_CenterPos can be used as a good biomarker in differential diagnosis of influenza A and B.

Key words: Influenza, Virus, Leukocyte morphological parameter, Monocyte forward scattered light central position