Influence of age and sex on TEG parameters in healthy subjects

doi:10.3969/j.issn.1673-8640.2019.10.003

Abstract

Abstract: Objective To study the influence of different ages and sex on thromboelastography（TEG） parameters[K（fibrinogen reaction time）,R（clotting time）,α angle（the grow rate of blood clot）and MA（maximum amplitude thrombus）],and to provide a reference for establishing appropriate reference intervals of TEG parameters. Methods A total of 2 935 healthy subjects were enrolled,and their TEG parameters were collected as research data. The cases were classified according to different ages and sex. The influence of different ages and sex on TEG parameters was evaluated. Results Among the 2 935 healthy subjects,there was no statistical significance for the parameter of K in different sex groups（P>0.05）. There was statistical significance in different sex groups for the parameters of R,α angle and MA（P<0.01）. Between <30-year-old and >40-year-old males,there was statistical significance for R,MA and α angle（P<0.01）. Between 31-40-year-old and the other age females,there was statistical significance for K,MA and α angle（P<0.01）. Between 31-40-year-old females and males,there was statistical significance for TEG parameters（P<0.01）. Conclusions TEG parameters are influenced by various ages and sex. The reference intervals of TEG parameters in adults should be established practically.

Key words: Thromboelastography, Age, Sex, Reference interval

CLC Number:

R446.1

ZHAO Yingmei, ZHANG Jue, HUANG Yan. Influence of age and sex on TEG parameters in healthy subjects[J]. Laboratory Medicine, 2019, 34(10): 881-884.

Figures/Tables 4

References 17

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组别	例数	年龄（岁）	性别		R值（min）	K值（min）	α角（°）	MA值（mm）
组别	例数	年龄（岁）	男	女	R值（min）	K值（min）	α角（°）	MA值（mm）
青年组	548	26.60±2.72	387	161	7.49±2.03	2.79±2.04	56.39±10.97	52.68±7.97
壮年组	802	35.40±2.75	564	238	7.32±1.89^*	2.63±1.95	58.21±10.78^*	54.59±7.50^*
中年组	616	45.36±2.97	364	252	7.15±1.95	2.65±1.81	58.15±11.37^*	54.92±7.86^*
中老年组	519	55.37±2.89	317	202	7.26±1.96	2.79±2.46	57.88±11.83^*	54.54±8.39^*
老年组	450	67.39±5.30	256	194	7.01±2.04^*#	2.60±1.61	58.53±11.35^*	54.82±7.81^*
合计	2 935	44.30±13.96	1 888	1 047	7.26±1.97	2.68±1.99	57.85±11.23	54.33±7.91

组别	例数	年龄（岁）	性别		R值（min）	K值（min）	α角（°）	MA值（mm）
组别	例数	年龄（岁）	男	女	R值（min）	K值（min）	α角（°）	MA值（mm）
青年组	548	26.60±2.72	387	161	7.49±2.03	2.79±2.04	56.39±10.97	52.68±7.97
壮年组	802	35.40±2.75	564	238	7.32±1.89^*	2.63±1.95	58.21±10.78^*	54.59±7.50^*
中年组	616	45.36±2.97	364	252	7.15±1.95	2.65±1.81	58.15±11.37^*	54.92±7.86^*
中老年组	519	55.37±2.89	317	202	7.26±1.96	2.79±2.46	57.88±11.83^*	54.54±8.39^*
老年组	450	67.39±5.30	256	194	7.01±2.04^*#	2.60±1.61	58.53±11.35^*	54.82±7.81^*
合计	2 935	44.30±13.96	1 888	1 047	7.26±1.97	2.68±1.99	57.85±11.23	54.33±7.91

组别	例数	年龄（岁）	R值（min）	K值（min）	α角（°）	MA值（mm）
青年组	387	26.54±3.09	7.51±2.07	2.86±2.16	55.76±10.76	52.33±7.62
壮年组	564	35.40±2.79	7.43±1.93	2.81±2.19	56.83±11.08	53.66±7.77^*
中年组	364	45.32±3.03	7.16±1.86^*	2.70±1.81	57.48±11.16^*	54.72±8.04^*#
中老年组	317	55.43±2.90	7.23±1.88	2.83±2.40	57.52±11.72^*	53.74±8.36^*
老年组	256	67.41±5.25	7.04±1.93^*#	2.65±1.53	57.93±10.80^*	54.61±7.70^*
合计	1 888	44.30±13.93	7.31±1.94	2.78±2.07	57.00±11.12	53.73±7.92

组别	例数	年龄（岁）	R值（min）	K值（min）	α角（°）	MA值（mm）
青年组	387	26.54±3.09	7.51±2.07	2.86±2.16	55.76±10.76	52.33±7.62
壮年组	564	35.40±2.79	7.43±1.93	2.81±2.19	56.83±11.08	53.66±7.77^*
中年组	364	45.32±3.03	7.16±1.86^*	2.70±1.81	57.48±11.16^*	54.72±8.04^*#
中老年组	317	55.43±2.90	7.23±1.88	2.83±2.40	57.52±11.72^*	53.74±8.36^*
老年组	256	67.41±5.25	7.04±1.93^*#	2.65±1.53	57.93±10.80^*	54.61±7.70^*
合计	1 888	44.30±13.93	7.31±1.94	2.78±2.07	57.00±11.12	53.73±7.92

组别	例数	年龄（岁）	R值（min）	K值（min）	α角（°）	MA（mm）
青年组	161	26.99±2.69	7.43±1.94	2.62±1.72^#	57.89±11.35^#	53.55±8.70
壮年组	238	35.42±2.64	7.07±1.76^*	2.18±1.10	61.49±9.26	56.80±6.30^*
中年组	252	45.41±2.90	7.14±2.08	2.56±1.81^#	59.10±11.63^#	55.20±7.59^*#
中老年组	202	55.35±2.87	7.30±2.09	2.72±2.54^#	58.44±12.01^#	55.80±8.32^*
老年组	194	67.37±5.39	6.98±2.18^*	2.53±1.70^#	59.32±12.02^#	55.10±7.96^*#
合计	1 047	44.29±13.94	7.17±2.01	2.51±1.82	59.37±11.29	55.41±7.77