Abstract:

Objective To investigate the influence of serum IgA level on serum fructosamine （FMN） level. Methods The levels of FMN and immunoglobulins in serum samples were analyzed for 247 newly-diagnosed multiple myeloma （MM） patients in 3 hospitals of Cangzhou from January 1,2012 to December 31,2015. A total of 50 patients with chronic liver diseases（CLD） who had high IgA levels were enrolled as control group．There were IgG type （133 cases）,IgA type （83 cases）and IgM type （31 cases）in the 247 MM patients. All the patients were excluded with diabetes mellitus. Results FMN levels of IgA type MM group were higher than those of control group（P<0.05）. There was no statistical significance among IgG type MM group,IgM type MM group and control group （P>0.05）. The IgA level of IgA type MM group is related positively to FMN level（r=0.785,P<0.05）,and the IgA level in control group has no correlation（r=0.241,P>0.05）. Conclusions IgA level should be considered,if FMN is elevated for unknown reasons．

Key words: Fructosamine, IgA, Multiple myeloma, Diabetes mellitus, Chronic liver diseases