Abstract:

Objective To evaluate the change of C-reactive protein（CRP） in cancer patients with infection,and to observe the relationships of CRP with neutrophil count and procalcitonin（PCT）. Methods The levels of CRP in 206 cancer patients with fever were determined,and the results of neutrophil count and infection status were analyzed. Among them,57 patients were followed up,and the change of CRP was evaluated,and the relationship with infection was analyzed. Results Among 206 cancer patients with fever,CRP level [median（quartile） ] in increased neutrophil count group was 119.95 （57.22,182.62） mg/L,which was higher than that in normal neutrophil count group [64.55（26.92,119.25） mg/L] and decreased neutrophil count group [80.45（42.00,123.35）mg/L]（P<0.05）. Among cancer patients with various kinds of fever,CRP levels in infection group and late-phase group were significantly higher than those in postoperative group,drug reaction group and other groups. For therapeutic effect assessment,CRP level in invalid treatment group was 101.00（69.50,143.00）mg/L,which was significantly higher than that in valid treatment group [10.00（4.00,27.00）mg/L]（P<0.05）. For disease monitoring,the change of CRP was similar to that of PCT. Conclusions CRP can be used as a diagnosis parameter for cancer patients with infection,and it is also an independent indicator for prognosis.

Key words: C-reactive protein, Procalcitonin, Cancer, Infection