Progress of vitamin D assay standardization

doi:10.3969/j.issn.1673-8640.2016.01.016

Abstract

Abstract:

The assay of serum 25-hydroxyvitamin D [25（OH）D] concentration is the best approach to assess human vitamin D status. However,it has also been recognized that there is substantial between-assay variability which clearly confounds the diagnosis and treatment of hypovitaminosis D. Therefore,to develop and implement evidence-based clinical guidelines,it is essential that 25（OH）D determination should be standardized in both clinical and research laboratories. In 2010,the Vitamin D Standardization Program was organized by the Ofﬁce of Dietary Supplements of the National Institutes of Health （NIH-ODS）. In this review,we outline a way toward achieving the Vitamin D Standardization Program.

Key words: 25-hydroxyvitamin D, Standardization, The Vitamin D Standardization Program

CLC Number:

R446.1

ZHOU Yan, PAN Baishen. Progress of vitamin D assay standardization[J]. Laboratory Medicine, 2016, 31(1): 71-75.

Figures/Tables 2

References 22

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项目	组成部分
参考测量程序	NIST：LC-MS/MS; 根特大学：LC-MS/MS
标准参考物质	NIST2972、972、972a
性能验证程序	CDC 标准化认证程序
PT/EQA	CAP、DEQAS、NIST-NIH、VitDQAP

项目	组成部分
参考测量程序	NIST：LC-MS/MS; 根特大学：LC-MS/MS
标准参考物质	NIST2972、972、972a
性能验证程序	CDC 标准化认证程序
PT/EQA	CAP、DEQAS、NIST-NIH、VitDQAP

实验室	CV	偏倚
参考实验室	≤5	≤1.7
常规检测实验室	≤10	≤5

实验室	CV	偏倚
参考实验室	≤5	≤1.7
常规检测实验室	≤10	≤5

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