Investigation on the reference intervals of first morning urine ACR and urinary albumin concentration among adults in Tianjin

doi:10.3969/j.issn.1673-8640.2015.12.007

Abstract

Abstract:

Objective To survey the reference intervals of urine albumin-creatinine ratio(ACR) and urinary albumin concentration in first morning urine samples from 20-60-year-old healthy subjects in Tianjin.Methods According to the inclusion criteria, 500 healthy subjects(20-60-year-old) were enrolled in this study. Their first morning urine samples were collected, and the concentration of urinary albumin (nephelometry immunoassay)and creatinine were determined, and urine ACR was calculated. According to the Clinical and Laboratory Standards Institute (CLSI) EP15-A and C28-A2, Z test was performed to analyze the data and was used to establish the reference intervals of urine ACR and urinary albumin concentration. Results There was no statistical significance among different ages in both male and female groups (P>0.05), and it was not necessary to establish the age-specific reference intervals for urine ACR and urinary albumin concentration. Males, on average, had higher urinary albumin concentration than females(P<0.05), and the sex-specific reference interval was needed. For urine ACR, there was no statistical significance with sex (P>0.05), and the uniform reference interval could be used in males and females. The distributions of urine ACR and urinary albumin concentration were skewed (P<0.05), so we used the 95th percentile(P₉₅) as the reference interval. The urine ACR reference interval was 0-12.40 mg/g, and the urinary albumin reference intervals were 0-18.72 mg/L for male and 0-14.27 mg/L for females. Conclusions The urine ACR and urinary albumin concentration reference intervals among healthy subjects in Tianjin are lower than those recommended by clinical guidelines. There is no sex difference for ACR. However, it exists sex difference for urinary albumin concentration, and it needs different reference intervals for males and females.

Key words: Albumin-creatinine ratio, Albumin, Urine, Biological reference interval, Healthy adult

CLC Number:

R446.1

CUI Xiaofan, LI Rong, WANG Huabin, LIU Rui, PAN Wenjie. Investigation on the reference intervals of first morning urine ACR and urinary albumin concentration among adults in Tianjin[J]. Laboratory Medicine, 2015, 30(12): 1193-1197.

Figures/Tables 4

性别	例数	年龄(岁)	体重指数(kg/m²)	收缩压(kPa)	舒张压(kPa)	空腹血糖(mmol/L)	TG(mmol/L)
男性	250	40.98±11.32	23.13±1.97	14.97±1.61	9.80±1.13	5.34±0.40	1.10±0.57
女性	250	40.14±11.22	21.90±2.15	13.91±1.79	9.52±1.12	5.11±0.42	0.93±0.40
〗性别	例数	TC (mmol/L)	LDL-C (mmol/L)	HDL-C (mmol/L)	尿白蛋白 (mg/L)	尿肌酐 (mmol/L)	ACR (mg/g)
男性	250	4.64±0.82	2.92±0.56	1.42±0.29	7.11(2.12~28.70)	13.25(1.88~29.11)	4.83(1.20~19.94)
女性	250	4.59±0.79	2.89±0.19	1.56±0.28	4.37(2.12~21.80)	7.39(1.43~25.40)	5.19(1.14~30.85)

组别	例数	尿白蛋白(mg/L)				ACR(mg/g)
组别	例数	$x ?$	s	范围	结论	$x ?$	s	范围	结论
男性
20~40岁组	125	8.15	5.23	2.12~28.70	Z<Z^*, s₂<1.5s₁,	5.28	2.97	1.20~19.94	Z<Z^*, s₂<1.5s₁,
41~60岁组	125	7.9	5.24	2.12~27.60	P>0.05	6.07	3.57	1.45~19.83	P>0.05
女性
20~40岁组	125	5.69	3.85	2.12~20.80	Z<Z^*, s₁<1.5s₂,	6.04	3.93	1.14~30.85	Z<Z^*, s₁<1.5s₂,
41~60岁组	125	4.47	3.69	2.12~21.80	P>0.05	6.19	3.14	1.53~20.48	P>0.05

组别	例数	尿白蛋白(mg/L)				ACR(mg/g)
组别	例数	$x ?$	s	范围	结论	$x ?$	s	范围	结论
男性
20~40岁组	125	8.15	5.23	2.12~28.70	Z<Z^*, s₂<1.5s₁,	5.28	2.97	1.20~19.94	Z<Z^*, s₂<1.5s₁,
41~60岁组	125	7.9	5.24	2.12~27.60	P>0.05	6.07	3.57	1.45~19.83	P>0.05
女性
20~40岁组	125	5.69	3.85	2.12~20.80	Z<Z^*, s₁<1.5s₂,	6.04	3.93	1.14~30.85	Z<Z^*, s₁<1.5s₂,
41~60岁组	125	4.47	3.69	2.12~21.80	P>0.05	6.19	3.14	1.53~20.48	P>0.05

性别	例数	尿白蛋白(mg/L)					ACR(mg/g)
性别	例数	$x ?$	s	范围	结论		$x ?$	s	范围	结论
男性	250	8.02	5.24	2.12~28.70	Z﹥Z^*, s₁>1.5s₂,	5.69	3.31	1.20~19.94	Z<Z^*, s₂<1.5s₁,
女性	250	5.09	3.81	2.12~21.80	P<0.05	6.11	3.56	1.14~30.85	P>0.05

性别	例数	尿白蛋白(mg/L)					ACR(mg/g)
性别	例数	$x ?$	s	范围	结论		$x ?$	s	范围	结论
男性	250	8.02	5.24	2.12~28.70	Z﹥Z^*, s₁>1.5s₂,	5.69	3.31	1.20~19.94	Z<Z^*, s₂<1.5s₁,
女性	250	5.09	3.81	2.12~21.80	P<0.05	6.11	3.56	1.14~30.85	P>0.05

性别	尿白蛋白(mg/L)				尿肌酐(mmol/L)				ACR(mg/g)
性别	P₂₅	P₅₀	P₇₅	P₉₅	P₂₅	P₅₀	P₇₅	P₉₅	P₂₅	P₅₀	P₇₅	P₉₅
男性	4.80	7.11	10.70	18.72	9.50	13.25	17.03	22.83	3.79	4.83	6.76	12.89
女性	2.77^*	4.37^*	6.84^*	14.27^*	4.78^*	7.39^*	11.43^*	16.20^*	4.29	5.19	6.99	13.34

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