The prospects of mass spectrometry application on microbiology

doi:10.3969/j.issn.1673-8640.2015.02.001

Abstract

Abstract:

The matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) technique can be used to generate protein fingerprint signatures from whole bacterial cells. By comparing these fingerprints to a database of reference spectra by the various algorithms, bacteria can be rapidly identified. MALDI-TOF MS can be used for accurate and rapid identification of various microorganisms, such as common bacteria, Nocardia, Mycobacterium, anaerobe, yeast and filamentous fungi. MALDI-TOF MS have recently been widely introduced. The characteristics of one review and four papers published in the special subject about MALDI-TOF MS were reviewed. The development of studies in MALDI-TOF MS will play an important role in the application of mass spectrometry in clinical microbiological laboratories.

Key words: Matrix-assisted laser desorption/ionization-time of flight mass spectrometry, Bacteria identification, Clinical microbiology laboratory

CLC Number:

R446.5

LUO Yanping. The prospects of mass spectrometry application on microbiology[J]. Laboratory Medicine, 2015, 30(2): 97-100.

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