Significance investigation of high-sensitivity cardiac troponin T for viral myocarditis in children

doi:10.3969/j.issn.1673-8640.2014.04.002

Abstract

Abstract:

Objective　To investigate the diagnosis and treatment significance of high-sensitivity cardiac troponin T （hs-cTnT）and creatine kinase isoenzyme mass （CK-MB mass） for viral myocarditis in children （VMC）. Methods　Serum levels of hs-cTnT and CK-MB mass were determined in 67 patients with VMC （measured within clinical symptoms for 2- 4 d and after treatment for 1 week）， 54 children with acute gastroenteritis， 53 children with acute upper respiratory tract infection， 50 children with acute pneumonia and 55 healthy children （healthy control group）. The receiver operating characteristic （ROC） curve was used to evaluate the sensitivity and specificity of hs-cTnT determination， CK-MB mass determination and the combined determination of hs-cTnT and CK-MB mass. Results　Serum levels of hs-cTnT in acute gastroenteritis group， acute upper respiratory tract infection group， acute pneumonia group， healthy control group and VMC group [median （quartile）] were 5.68（3.83， 8.22）， 5.03（3.00， 6.57）， 5.52（3.44， 10.19）， 4.81（3.22， 6.67）and 58.57（29.77， 160.20）pg/mL， respectively， and serum levels of CK-MB mass [median （quartile）] were 2.29（1.72， 2.96）， 2.26（1.41， 3.48）， 2.59（1.81， 3.62）， 1.83（1.42， 3.05） and 7.40（4.32， 13.26） ng/mL， respectively. There was statistical significance for hs-cTnT and CK-MB mass among the groups （H=115.15 and 83.79，P<0.001）. Serum levels of hs-cTnT and CK-MB mass in VMC group after treatment were lower than those within clinical symptoms for 2- 4 d （P<0.001）， which were significantly higher than those in the acute gastroenteritis group， acute upper respiratory tract infection group， acute pneumonia group and healthy control group （P<0.001）. The ROC curve showed that the combined determination of hs-cTnT and CK-MB mass had higher sensitivity than hs-cTnT determination （P<0.05）， but without significant specificity （P>0.05）. Conclusions　The hs-cTnT has high diagnosis sensitivity and specificity for VMC， and the combined determination of hs-cTnT and CK-MB mass has high diagnosis significance.

Key words: High-sensitivity cardiac troponin T, Creatine kinase isoenzyme mass, Viral myocarditis, Diagnosis

CLC Number:

R446.1

HU Xiaobin，XIANG Xiaojie，GUO Xiaocong，CHEN Huagang，FANG Hua，LU Xinmin.. Significance investigation of high-sensitivity cardiac troponin T for viral myocarditis in children[J]. , 2014, 29(4): 307-311.

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