The influence of hepatitis B virus on the expression of insulin-like growth factor-binding protein 7 and its clinical significance

doi:10.3969/j.issn.1673-8640.2013.12.007

Abstract

Abstract:

Objective　 To investigate the influence of hepatitis B virus(HBV) on the expression of insulin-like growth factor-binding protein 7(IGFBP7) and its clinical significance. Methods　 The mRNA expression of IGFBP7 was measured by reverse transcription-polymerase chain reaction (PCR), and serum levels of IGFBP7 were measured by enzyme-linked immunosorbent assay(ELISA). The different expressions of IGFBP7 among patients with chronic hepatitis B(CHB), liver cirrhosis(LC) and hepatocellular carcinoma(HCC) were analyzed. Results　 The expression of IGFBP7 mRNA was higher in HepG2.2.15 cells than in HepG2 cells. Compared with healthy controls, serum IGFBP7 levels were much higher in HBV patients (P<0.05), and the serum levels of IGFBP7 were detected at lower levels in patients with LC and HCC than those with CHB(P<0.05). Conclusions　 HBV can upregulate the expression of IGFBP7, which is negatively correlated with the disease progression.

Key words: Hepatitis B virus, Insulin-like growth factor-binding protein 7, Liver cirrhosis, Hepatocellular carcinoma

CLC Number:

R446.62

SONG Hui,LIU Xinghui,ZHU Chengliang, ZHOANG Jida,LI Yi.. The influence of hepatitis B virus on the expression of insulin-like growth factor-binding protein 7 and its clinical significance[J]. , 2013, 28(12): 1092-1094.

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The influence of hepatitis B virus on the expression of insulin-like growth factor-binding protein 7 and its clinical significance

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