关键词: 载脂蛋白E, 基因多态性, 心脑血管疾病, 黎族, 载脂蛋白E, 基因多态性, 心脑血管疾病, 黎族

Abstract: Objective　To study the apolipoprotein E (apo E) gene polymorphism in Li population patients with cardiovascular and cerebrovascular disease, and investigate the relationship of polymorphism with cardiovascular and cerebrovascular disease. Methods　The ligase detection reaction (LDR) technique was used to detect apo E gene polymorphism in 150 patients with cardiovascular and cerebrovascular disease (50 patients with hypertension， 50 patients with cerebral infarction and 50 patients with coronary artery disease) and 50 healthy controls. The results were analyzed. Results　In the disease group and control group, ε3/3 genotype frequency was the highest. The ε2 allel frequency in cerebral infarction group was lower than those in hypertension group, coronary artery disease group and  control group (P<0.05). There was no statistical significance in the allels among the hypertension, coronary artery disease and control groups (P>0.05). Conclusions　The apo E ε2 allel may be a major factor to reduce the incidence of cerebral infarction in Li population.

Key words: Apolipoprotein E, Gene polymorphism, Cardiovascular and cerebrovascular disease, Li population, Apolipoprotein E, Gene polymorphism, Cardiovascular and cerebrovascular disease, Li population