循环微粒的研究进展

doi:10.3969/j.issn.1673-8640.2017.011.027

摘要/Abstract

摘要：

微粒（MP）是细胞活化和凋亡时脱落产生的囊泡,大小为0.1~1.0 μm,可以转移多肽类、蛋白质、磷脂类、DNA及mRNA等。多种方法可以用于检测MP,目前主要应用流式细胞术。随着对MP研究的深入,人们发现MP与多种疾病如肿瘤、感染等的发生、发展有关,在疾病的诊断、治疗中有着较大的应用潜力。

关键词: 微粒, 流式细胞术, 疾病, 诊断

Abstract:

Microparticles（MP） are vesicles that release from active or apoptosis cells,with size ranging from 0.1 μm to 1.0 μm. MP are capable of transferring peptides,proteins,lipid components,DNA and mRNA. Methods of MP determination are various,and the most common approach is flow cytometry. As the study of MP is deeper and deeper,it is found that MP are relevant with the development of cancers,infections and other diseases,with large diagnostic and therapeutic potential.

Key words: Microparticle, Flow cytometry, Disease, Diagnosis

中图分类号:

R446.62

张云聪, 崔婵娟, 乔蕊, 张捷. 循环微粒的研究进展[J]. 检验医学, 2017, 32(11): 1059-1064.

ZHANG Yuncong, CUI Chanjuan, QIAO Rui, ZHANG Jie. Research progress in circulating microparticles[J]. Laboratory Medicine, 2017, 32(11): 1059-1064.

图/表 1

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