脂蛋白（a）——血脂家族的重要一员

doi:10.3969/j.issn.1673-8640.2017.07.002

摘要/Abstract

摘要：

脂蛋白（a）[Lp（a）]是血脂家族中特殊的一员,由低密度脂蛋白（LDL）样微粒和载脂蛋白（apo）（a）构成。血浆Lp（a）水平主要由遗传因素决定,主要受LPA基因位点kringle Ⅳ拷贝数多态性和单核苷酸多态性影响。由于Lp（a）分子大小差异很大,因此其检测方法尚未完全标准化。已有大量研究证实Lp（a）与心血管疾病（CVD）的发生、发展相关,其可能具有促炎、促动脉粥样硬化和促血栓作用。文章对Lp （a）的结构、代谢、遗传特点、测定方法及其与CVD的相关性进行了综述。

关键词: 脂蛋白（a）, 载脂蛋白（a）, LPA基因, 心血管疾病

Abstract:

Lipoprotein （a） [Lp（a）] consists of a low-density lipoprotein （LDL）-like particle and apolipoprotein （apo）（a） . The level of plasma Lp（a） is mainly determined by its genetic factors,including highly polymorphic copy number variation of kringleⅣ repeats and single nucleotide polymorphism at LPA gene locus. Due to its size variation,the standardization of Lp（a） determination is uncertain. It has been confirmed that there is an association between elevated Lp（a） and cardiovascular disease （CVD） in numerous studies. Lp（a） may have pro-inflammatory, pro-atherogenic and pro-thrombogenic properties and thus causes or promotes CVD. This review mainly focuses on Lp（a） structure,metabolism,genetics,determination and its relationship with CVD.

Key words: Lipoprotein（a）, Apolipoprotein（a）, LPA gene, Cardiovascular disease

中图分类号:

R446.1

乔蕊, 张捷. 脂蛋白（a）——血脂家族的重要一员[J]. 检验医学, 2017, 32(7): 561-565.

QIAO Rui, ZHANG Jie. Lipoprotein （a）：a vital member of blood lipid items[J]. Laboratory Medicine, 2017, 32(7): 561-565.

图/表 1

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