强直性脊柱炎患者血脂水平及与疾病活动度的相关性

doi:10.3969/j.issn.1673-8640.2017.05.005

摘要/Abstract

摘要：

目的探讨强直性脊柱炎（AS）患者血脂水平与疾病活动度的相关性。方法检测314例AS患者和138名健康体检者（正常对照组）总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和C反应蛋白（CRP）水平,并分析其与疾病活动度的相关性。结果与正常对照组比较,AS组TG水平和LDL-C/HDL-C比值明显升高（P<0.01）,TC、HDL-C、LDL-C水平明显降低（P<0.01）。AS患者CRP与TC、TG、HDL-C、LDL-C呈明显负相关（r值分别为-0.298、-0.198、-0.256、-0.259,P值分别为0.001、<0.001、<0.001、<0.001）。按CRP水平将AS患者分为3组[CRP低水平组（CRP≤10 mg/L）、CRP中水平组（CRP为>10~<50 mg/L）、CRP高水平组（CRP≥50 mg/L）],CRP高水平组TC、TG、HDL-C、LDL-C水平均低于CRP低水平组（P<0.01）,各组间LDL-C/HDL-C比值差异无统计学意义（P>0.05）。结论 AS患者血脂代谢存在异常,且血脂水平与患者炎症水平有关。

关键词: 血脂, 强直性脊柱炎, 心血管疾病

Abstract:

Objective To study the correlation of blood lipid levels with ankylosing spondylitis （AS）. Methodse A total of 314 AS patients and 138 healthy subjects （healthy control group） were enrolled. Total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein cholesterol（LDL-C）,high-density lipoprotein cholesterol（HDL-C） and C-reactive protein（CRP） were determined. The correlation of blood lipid levels with AS was evaluated. Results Compared with healthy control group,AS group had increased level of TG and LDL-C/HDL-C ratio （P<0.01） and decreased levels of TC,HDL-C and LDL-C （P<0.01）. TC,TG,HDL-C and LDL-C in AS group were negatively correlated with CRP （r=-0.298,-0.198,-0.256 and -0.259,P=0.001,<0.001,<0.001 and <0.001）. According to CRP levels,AS group was sub-classified into low-level CRP group （CRP≤10 mg/L）,middle-level CRP group （CRP>10-<50 mg/L） and high-level CRP group （CRP≥50 mg/L）. Compared with high-level CRP group,TC,TG,HDL-C and LDL-C were lower than those in low-level CRP group （P<0.01）. There was no statistical significance for LDL-C/HDL-C ratio among the groups （P>0.05）. Conclusions AS patients have blood lipid metabolic disorder. Their blood lipid levels may be correlated with inflammation status.

Key words: Blood lipid, Ankylosing spondylitis, Cardiovascular diseases

中图分类号:

R446.1

武志强, 杨滨, 冯伟华, 陈捷, 黄亨建. 强直性脊柱炎患者血脂水平及与疾病活动度的相关性[J]. 检验医学, 2017, 32(5): 370-373.

WU Zhiqiang, YANG Bin, FENG Weihua, CHEN Jie, HUANG Hengjian. Correlation of blood lipid levels with ankylosing spondylitis[J]. Laboratory Medicine, 2017, 32(5): 370-373.

图/表 4

参考文献 14

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组别	AS家族史（例）	CRP （mg/L）	HLA-B27（+）（例）
AS组	16	1.01~168.00	314
正常对照组	-	<10.00	-

组别	AS家族史（例）	CRP （mg/L）	HLA-B27（+）（例）
AS组	16	1.01~168.00	314
正常对照组	-	<10.00	-

组别	例数	TG（mmol/L）	TC（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	LDL-C/HDL-C比值
AS组	314	1.16±0.84	4.22±0.95	1.33±0.36	2.39±0.74	1.92±0.76
正常对照组	138	1.04±0.34	4.65±0.59	1.59±0.37	2.58±0.55	1.72±0.58
P值		0.024	<0.001	<0.001	0.003	0.002

组别	例数	TG（mmol/L）	TC（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）	LDL-C/HDL-C比值
AS组	314	1.16±0.84	4.22±0.95	1.33±0.36	2.39±0.74	1.92±0.76
正常对照组	138	1.04±0.34	4.65±0.59	1.59±0.37	2.58±0.55	1.72±0.58
P值		0.024	<0.001	<0.001	0.003	0.002

项目	TG			TC			HDL-C			LDL-C
项目	B值	R²值	P值	B值	R²值	P值	B值	R²值	P值	B值	R²值	P值
性别	0.011		0.487	-0.197		0.261	0.250		<0.001	-0.266		0.031
年龄	-0.232	0.113	0.001	0.023	0.179	<0.001	0.005	0.216	<0.001	0.015	0.147	<0.001
CRP	-0.005		0.354	-0.010		0.005	-0.003		<0.001	-0.007		0.032