检验医学 ›› 2014, Vol. 29 ›› Issue (10): 1059-1063.DOI: 10.3969/j.issn.1673-8640.2014.10.019

• 综述与讲座 • 上一篇    下一篇

多功能性T细胞在感染控制中的作用

乔丹1, 综述, 吴文娟2, 审校   

  1. 1.上海交通大学医学院附属瑞金医院北院检验科,上海 201800;2.上海市东方医院南院医学检验科,上海 200123
  • 收稿日期:2014-01-08 出版日期:2014-10-30 发布日期:2014-10-22
  • 通讯作者: 吴文娟,联系电话:021-20334503。
  • 作者简介:乔 丹,女,1984年生,博士,技师,主要从事病原微生物快速诊断及耐药性研究。
  • 基金资助:

    上海交通大学医学院附属瑞金医院北院院内课题(2014ZY06)

The role of polyfunctional T cells in infection control

QIAO Dan1, WU Wenjuan   

  1. 1.Department of Clinical Laboratory, Ruijin Hospital (North), Shanghai Jiaotong University School of Medicine, Shanghai 201800, China;
    2.Department of Clinical Laboratory, East Hospital (South), Shanghai 200123, China;
  • Received:2014-01-08 Online:2014-10-30 Published:2014-10-22

摘要:

多功能性T细胞能够分泌多种细胞因子并具有增殖能力,在慢性感染中具有更强的免疫调节功能。T 细胞反应的质量对于各种感染性疾病的预后具有关键的作用。了解不同T细胞亚群,特别是抗原特异性T细胞亚群在数量和功能方面的改变,对于感染性疾病的诊断和预后、各种感染和肿瘤的预防性或治疗性疫苗的研制具有非常关键的作用。

关键词: 多功能性T 细胞, 细胞因子, 感染控制

Abstract:

Polyfunctional T cells can secrete a variety of cytokines and have the ability of proliferation, which are strong in the control of chronic infection. The quality of T cell response has a key role in the prognosis of a variety of infectious diseases. Understanding the different T cell subsets, especially the changes of antigen-specific T cell subsets in amount and function, it is crucial for the diagnosis and prognosis of infectious diseases and for the design of various infections and cancer preventive or therapeutic vaccine.

Key words: Polyfunctional T cell, Cytokine, Infection control

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