孕中期妊娠期糖尿病患者血清抵抗素与胰岛素抵抗的关系

doi:10.3969/j.issn.1673-8640.2014.09.012

检验医学 ›› 2014, Vol. 29 ›› Issue (9): 921-924.DOI: 10.3969/j.issn.1673-8640.2014.09.012

孕中期妊娠期糖尿病患者血清抵抗素与胰岛素抵抗的关系

柯慧慧¹,郭丽梅¹,丁海英¹,许依群¹,顾佳士¹,严育忠²,杨晓宁¹

1. 上海市浦东医院妇产科,上海 201300;
2. 上海市浦东医院检验科,上海 201300

收稿日期:2013-12-01 出版日期:2014-09-30 发布日期:2014-09-25
通讯作者: 杨晓宁,联系电话:021-58022995
作者简介:柯慧慧,女,1982年生,学士,主治医师,主要从事妊娠期糖尿病研究
基金资助:
上海市浦东新区科技发展基金创新基金资助项目(PKJ-2011-Y25)

The relationships between the serum levels of resistin and insulin resistance among pregnant women with gestational diabetes mellitus in mid-pregnancy

KE Huihui¹, GUO Limei¹, DING Haiying¹, XU Yiqun¹, GU Jiashi¹, YAN Yuzhong², YANG Xiaoning¹

1. Department of Obstetrics and Gynecology, Shanghai Pudong Hospital, Shanghai 201300, China;
2. Department of Clinical Laboratory, Shanghai Pudong Hospital, Shanghai 201300, China

Received:2013-12-01 Online:2014-09-30 Published:2014-09-25

摘要/Abstract

摘要： 目的探讨妊娠期糖尿病(GDM)患者孕中期血清抵抗素水平与胰岛素抵抗(IR)的关系及其在GDM发病中的作用。方法以98例孕中期(24～28周)GDM患者为GDM组,以同期95名孕中期健康孕妇为对照组。分别采用酶联免疫吸附试验(ELISA)、葡萄糖氧化酶法和电化学发光法测定两组孕妇空腹血清抵抗素、空腹血糖(FBG)和空腹胰岛素(FINS)。计算稳态模型胰岛素抵抗指数(HOMA-IR)。比较两组血清抵抗素水平和IR程度的差异,分析抵抗素与GDM患者IR之间的关系。结果 GDM组血清中抵抗素、FBG、FINS及HOMA-IR水平分别为(19.74±6.89)μg/mL、(5.35±1.23)mmol/L、(21.77±7.83)mU/L及5.24±2.65,均明显高于对照组[(15.62±4.19)μg/mL、(4.34±0.43)mmol/L、(17.81±4.92)mU/L、3.43±1.00,P<0.05]。GDM组血清抵抗素水平与HOMA-IR呈明显正相关(r＝0.459,P<0.05)。结论抵抗素与HOMA-IR关系密切,提示抵抗素可能参与了GDM患者IR的发生。

关键词: 抵抗素, 胰岛素抵抗, 妊娠期糖尿病

Abstract: Objective To investigate the relationships between the serum levels of resistin and insulin resistance(IR) among pregnant women with gestational diabetes mellitus (GDM) in mid-pregnancy and its role in the progress of GDM. Methods A total of 98 GDM pregnant women (24-28 weeks) were enrolled as GDM group, and 95 healthy pregnant women (24-28 weeks) at the same period were enrolled as control group. The serum levels of resistin, fasting blood glucose(FBG) and fasting insulin(FINS) of all pregnant women were determined by enzyme-linked immunosorbent assay (ELISA), glucose oxidase method and electrochemiluminescence immunoassay, respectively. The home model insulin resistance index(HOMA-IR) was calculated. The difference of serum resistin and IR levels in the 2 groups were compared. The correlations between serum resistin and IR levels were analyzed. Results The serum levels of resistin, FBG, FINS and HOMA-IR in GDM group were (19.74±6.89)μg/mL, (5.35±1.23)mmol/L, (21.77±7.83)mU/L and 5.24±2.65, and those in control group were (15.62±4.19)μg/mL, (4.34±0.43)mmol/L, (17.81±4.92)mU/L and 3.43±1.00 (P<0.05). The serum levels of resistin were positively correlated with HOMA-IR(r=0.459, P<0.05). Conclusions The serum levels of resistin are closely correlated with HOMA-IR. Resistin probably plays its role in the progress of GDM.

Key words: Resistin, Insulin resistance, Gestational diabetes mellitus

中图分类号:

R446.1

柯慧慧,郭丽梅,丁海英,许依群,顾佳士,严育忠,杨晓宁. 孕中期妊娠期糖尿病患者血清抵抗素与胰岛素抵抗的关系[J]. 检验医学, 2014, 29(9): 921-924.

KE Huihui, GUO Limei, DING Haiying, XU Yiqun, GU Jiashi, YAN Yuzhong, YANG Xiaoning. The relationships between the serum levels of resistin and insulin resistance among pregnant women with gestational diabetes mellitus in mid-pregnancy[J]. , 2014, 29(9): 921-924.

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孕中期妊娠期糖尿病患者血清抵抗素与胰岛素抵抗的关系

The relationships between the serum levels of resistin and insulin resistance among pregnant women with gestational diabetes mellitus in mid-pregnancy

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