棕色脂肪组织在改善胰岛素抵抗中的作用研究进展

doi:10.3969/j.issn.1673-8640.2023.03.019

检验医学 ›› 2023, Vol. 38 ›› Issue (3): 297-300.DOI: 10.3969/j.issn.1673-8640.2023.03.019

棕色脂肪组织在改善胰岛素抵抗中的作用研究进展

孙文苑, 王攀, 崔丽艳()

北京大学第三医院检验科，北京 100191

收稿日期:2021-05-06 修回日期:2022-10-01 出版日期:2023-03-28 发布日期:2023-05-24
通讯作者: 崔丽艳
作者简介:崔丽艳，E-mail：cliyan@163.com。
孙文苑，女，1990年生，学士，主管技师，主要从事临床生化检验工作。
基金资助:
国家自然科学基金项目(61771022);国家自然科学基金项目(62071011)

Role of brown adipose tissue in insulin resistance and its research progress

SUN Wenyuan, WANG Pan, CUI Liyan()

Department of Clinical Laboratory，Peking University Third Hospital，Beijing 100191，China

Received:2021-05-06 Revised:2022-10-01 Online:2023-03-28 Published:2023-05-24
Contact: CUI Liyan

摘要/Abstract

摘要：

棕色脂肪组织是存在于哺乳动物体内的，由棕色脂肪细胞和血管基质成分组成的一种特殊脂肪，参与糖代谢、脂代谢，在胰岛素抵抗（IR）中发挥重要作用。一方面，棕色脂肪细胞的产热作用使耗能增加；另一方面，来源于棕色脂肪组织的因子以自分泌或旁分泌的形式作用于多个组织，调节能量消耗、摄食行为和胰岛素敏感性等。文章简述了棕色脂肪组织的功能及其分泌的因子，概述其在动物模型和人体的相关研究进展，总结棕色脂肪组织对IR的改善作用。

关键词: 棕色脂肪组织, 胰岛素抵抗, 解偶联蛋白1, 糖代谢

Abstract:

Brown adipose tissue is a kind of special fat in mammals，which is composed of brown adipocytes and stromal vascular fraction. It is involved in glucose and lipid metabolism and plays a role in insulin resistance（IR）. The thermogenic effect of brown adipocytes increases energy consumption，and secretary factors from brown adipocytes act in autocrine or paracrine forms in multiple tissues to regulate energy consumption，feeding behavior and insulin sensitivity. In this review，the function and secretion factors of brown adipose tissue are summarized. The research progress of brown adipose tissue in animal model and human body is summarized. The effect brown adipose tissue on IR improvement is discussed.

Key words: Brown adipose tissue, Insulin resistance, Uncoupling protein 1, Glucose metabolism

中图分类号:

R446.1

孙文苑, 王攀, 崔丽艳. 棕色脂肪组织在改善胰岛素抵抗中的作用研究进展[J]. 检验医学, 2023, 38(3): 297-300.

SUN Wenyuan, WANG Pan, CUI Liyan. Role of brown adipose tissue in insulin resistance and its research progress[J]. Laboratory Medicine, 2023, 38(3): 297-300.

参考文献 31

[1]	WANG L, WANG S, SHI Y, et al. YAP and TAZ protect against white adipocyte cell death during obesity[J]. Nat Commun, 2020, 11(1):5455. DOI PMID
[2]	IKEDA K, YAMADA T. UCP1 dependent and independent thermogenesis in brown and beige adipocytes[J]. Front Endocrinol(Lausanne), 2020, 11:498.
[3]	ORMAZABAL V, NAIR S, ELFEKY O, et al. Association between insulin resistance and the development of cardiovascular disease[J]. Cardiovasc Diabetol, 2018, 17(1):122. DOI PMID
[4]	FRIGOLET M E, GUTIÉRREZ-AGUILAR R. The role of the novel lipokine palmitoleic acid in health and disease[J]. Adv Nutr, 2017, 8(1):173S-181S. DOI URL
[5]	MIAO Z, ALVAREZ M, KO A, et al. The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance[J]. PLoS Genet, 2020, 16(9):e1009018. DOI URL
[6]	陈宏锦, 潘晓茜, 高平进, 等. 棕色脂肪组织与心血管疾病的关系[J]. 中华细胞与干细胞杂志(电子版), 2020, 10(3):182-186.
[7]	BECHER T, PALANISAMY S, KRAMER D J, et al. Brown adipose tissue is associated with cardiometabolic health[J]. Nat Med, 2021, 27(1):58-65. DOI PMID
[8]	NISHIMURA T, MOTOI M, EGASHIRA Y, et al. Seasonal variation of non-shivering thermogenesis(NST) during mild cold exposure[J]. J Physiol Anthropol, 2015, 34(1):11. DOI URL
[9]	FISCHER A W, BEHRENS J, SASS F, et al. Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice[J]. J Lipid Res, 2020, 61(11):1377-1389. DOI PMID
[10]	HARMS M, SEALE P. Brown and beige fat:development,function and therapeutic potential[J]. Nat Med, 2013, 19(10):1252-1263. DOI
[11]	ASSEFA B, MAHMOUD A M, PFEIFFER A F H, et al. Insulin-like growth factor(IGF) binding protein-2,independently of IGF-1,induces GLUT-4 translocation and glucose uptake in 3T3-L1 adipocytes[J]. Oxid Med Cell Longev, 2017, 2017:3035184.
[12]	GHARANEI S, SHABIR K, BROWN J E, et al. Regulatory microRNAs in brown,brite and white adipose tissue[J]. Cells, 2020, 9(11):2489. DOI URL
[13]	MÖSSENBÖCK K, VEGIOPOULOS A, ROSE A J, et al. Browning of white adipose tissue uncouples glucose uptake from insulin signaling[J]. PLoS One, 2014, 9(10):e110428. DOI URL
[14]	KWON H J, SAHA A, AHN SY, et al. Polymethoxyselenoflavones exert anti-obesity effects through activation of lipolysis and brown adipocyte metabolism[J]. Int J Obes(Lond), 2021, 45(1):122-129. DOI
[15]	OLSEN J M, SATO M, DALLNER O S, et al. Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation[J]. J Cell Biol, 2014, 207(3):365-374. DOI PMID
[16]	LEITNER B P, HUANG S, BRYCHTA R J, et al. Mapping of human brown adipose tissue in lean and obese young men[J]. Proc Natl Acad Sci U S A, 2017, 114(32):8649-8654. DOI URL
[17]	GÓMEZ-HERNÁNDEZ A, OTERO Y F, DE LAS HERAS N, et al. Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction[J]. Endocrinology, 2012, 153(3):1242-1255. DOI URL
[18]	MESA A M, MEDRANO T I, SIROHI V K, et al. Identification and characterization of novel abdominal and pelvic brown adipose depots in mice[J]. Adipocyte, 2022, 11(1):616-629. DOI PMID
[19]	LIU D, BORDICCHIA M, ZHANG C, et al. Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning[J]. J Clin Invest, 2016, 126(5):1704-1716. DOI PMID
[20]	HANSSEN M J, WIERTS R, HOEKS J, et al. Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance[J]. Diabetologia, 2015, 58(3):586-595. DOI PMID
[21]	SOUNDARRAJAN M, DENG J, KWASNY M, et al. Activated brown adipose tissue and its relationship to adiposity and metabolic markers:an exploratory study[J]. Adipocyte, 2020, 9(1):87-95. DOI URL
[22]	刘玲, 刘思佳, 刘洋, 等. PAQR9对棕色脂肪产热及UCP1表达的影响[J]. 复旦学报(医学版), 2020, 47(6):816-824.
[23]	RUI L. Brown and beige adipose tissues in health and disease[J]. Compr Physiol, 2017, 7(4):1281-1306. DOI PMID
[24]	武晓慧, 李青, 魏婉丽, 等. Jmjd3维持小鼠棕色脂肪细胞脂滴及线粒体的形态和功能[J]. 中南大学学报(医学版), 2020, 45(11):1298-1307.
[25]	CARPENTIER A C, BLONDIN D P, VIRTANEN K A, et al. Brown adipose tissue energy metabolism in humans[J]. Front Endocrinol(Lausanne), 2018, 9:447.
[26]	PAYAB M, ABEDI M, FOROUGHI HERAVANI N, et al. Brown adipose tissue transplantation as a novel alternative to obesity treatment:a systematic review[J]. Int J Obes(Lond), 2021, 45(1):109-121. DOI
[27]	ROSELL M, KAFOROU M, FRONTINI A, et al. Brown and white adipose tissues:intrinsic differences in gene expression and response to cold exposure in mice[J]. Am J Physiol Endocrinol Metab, 2014, 306(8):E945-E964. DOI URL
[28]	VILLARROYA J, CEREIJO R, VILLARROYA F. An endocrine role for brown adipose tissue?[J]. Am J Physiol Endocrinol Metab, 2013, 305(5):E567-E572. DOI URL
[29]	MA Y, GAO M, LIU D. Preventing high fat diet-induced obesity and improving insulin sensitivity through neuregulin 4 gene transfer[J]. Sci Rep, 2016, 6:26242. DOI PMID
[30]	CHEN Z, WANG G X, MA S L, et al. Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders[J]. Mol Metab, 2017, 6(8):863-872. DOI PMID
[31]	葛李娜, 杨进, 洪天配. 成纤维细胞生长因子21在血糖调节中的作用及其治疗学意义[J]. 中华糖尿病杂志, 2018, 10(6):4.

棕色脂肪组织在改善胰岛素抵抗中的作用研究进展

Role of brown adipose tissue in insulin resistance and its research progress

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 31

相关文章 15

编辑推荐

Metrics

[1]	区苑清, 赵凡, 叶爱莲, 李立峰, 赵海桃, 黎惠贞, 梁焯辉, 李粮. 血浆网膜素1水平与2型糖尿病患者代谢清除率的关系[J]. 检验医学, 2022, 37(1): 28-31.
[2]	左雪灿, 楚艳玲, 李占平. T2DM合并微血管病变患者凝血四项与C肽、IR水平的关系[J]. 检验医学, 2020, 35(4): 327-328.
[3]	刘晓妮, 王颖, 李桃桃, 马小敏, 赵换牢. 2型糖尿病合并代谢综合征患者胰岛素抵抗指数与慢性炎症指标相关性研究[J]. 检验医学, 2019, 34(9): 826-830.
[4]	王炜城, 杨琼. 甲状腺功能亢进症患者血清胎球蛋白A水平与胰岛素抵抗相关性研究[J]. 检验医学, 2019, 34(10): 901-904.
[5]	陈效琴, 任静. 游离脂肪酸、胰岛素抵抗与代谢综合征相关因素的关系[J]. 检验医学, 2016, 31(7): 553-558.
[6]	管琳, 林晓, 胡振飞. 甲状腺功能减低对妊娠期糖耐量及血红蛋白的影响[J]. 检验医学, 2015, 30(1): 90-91.
[7]	柯慧慧,郭丽梅,丁海英,许依群,顾佳士,严育忠,杨晓宁. 孕中期妊娠期糖尿病患者血清抵抗素与胰岛素抵抗的关系[J]. 检验医学, 2014, 29(9): 921-924.
[8]	张岩，陈晓亭，宋惠珠，亓志刚. 肥胖所导致的胰岛素抵抗分子机制的研究进展[J]. 检验医学, 2014, 29(7): 774-777.
[9]	须静,胡晓波. 2型糖尿病患者铁蛋白浓度与胰岛素抵抗的相关性研究[J]. 检验医学, 2013, 28(9): 805-808.
[10]	崔卫东. 空腹血清游离脂肪酸与2型糖尿病的相关性分析[J]. 检验医学, 2013, 28(7): 637-638.
[11]	陆秋涯;迟贞旎;陆怡德. 空腹血清游离脂肪酸与2型糖尿病的关系[J]. 检验医学, 2012, 27(9): 725-727.
[12]	徐宜清. 妊娠早期高尿酸血症的临床意义分析[J]. 检验医学, 2012, 27(7): 606-608.
[13]	张　铭;张一鸣;巢浩界;魏梓文. α2-HS糖蛋白与妊娠期糖尿病关系的研究[J]. 检验医学, 2012, 27(3): 181-184.
[14]	王依屹，张珏，鲁传翠. 2型糖尿病患者胰岛素抵抗与血清游离脂肪酸浓度关系[J]. 检验医学, 2012, 27(10): 806-808.
[15]	李新征;陈宝炳;康云平. 非酒精性脂肪肝患者血清游离脂肪酸与胰岛素抵抗的关系[J]. 检验医学, 2012, 27(1): 48-49.