关键词: 葡糖氨基葡聚糖, 丙二醛, 非霍奇金淋巴瘤

Abstract:

Objective To investigate the significance of glycosaminoglycan (GAG) and malondialdehyde (MDA) in the diagnosis and treatment of non-Hodgkin's lymphoma(NHL). Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of serum GAG and MDA in 99 NHL patients and 58 healthy controls. The chemotherapy efficiency in 20 follicular lymphoma (FL) patients were followed and monitored, and the results were analyzed and compared by nonparametric rank sum test. Results The levels of serum GAG and MDA in 99 NHL patients were significantly higher than those in healthy controls (P<0.01), especially in FL patients(P<0.01).The progress of GAG level in 20 followed-up FL patients was consistent with disease progression (consistency rate>75%), while the progress of MDA level was not entirely consistent with disease progression. Conclusions GAG and MDA have a useful clinical application significance in the diagnosis and treatment monitoring of NHL.

Key words: Glycosaminoglycan, Malondialdehyde, Non-Hodgkin's lymphoma