播散性隐球菌病病例分析

doi:10.3969/j.issn.1673-8640.2025.04.014

摘要/Abstract

摘要：

隐球菌病是由隐球菌引起的一种亚急性、慢性或急性真菌病，患者死亡率高。文章分析1例经血清学、脑脊液检查、组织病理学检查、病原体培养、表型分析、分子鉴定等诊断为新型隐球菌格鲁比变种播散性隐球菌病的少见隐球菌病病例。同时，分析近10年相关文献报道的56例隐球菌病病例，以帮助临床深入认识该病，为此类少见真菌病的早诊早治提供参考。

中图分类号:

R379.5

康俞莉, 李莉, 陈果, 王艺静, 张立, 章强强, 赵颖. 播散性隐球菌病病例分析[J]. 检验医学, 2025, 40(4): 393-399.

图/表 6

图1 皮肤检查结果注：（a）~（d）面部、腹部可见红色斑丘疹、结节；（e）左肘暗红斑；（f）左膝暗红斑伴有斑痕形成。

图2 组织病理检查结果注：（a）表皮部分破溃伴脓痂（HE×10）；（b）真皮内大量炎症细胞浸润（HE×40）；（c）炎症区域内可见大量PAS染色阳性孢子（×400）。

图3 皮肤组织嗜银染色结果注：（a）孢子散在或聚集分布，部分芽生（+）（×400）；（b）孢子聚集分布，可见深黑色厚壁荚膜（×1 000）。

图4 皮损组织涂片墨汁染色结果注：皮损组织直接镜检，可见散在或聚集分布的厚壁荚膜孢子（×400）。

图5 皮损组织菌落图注：奶油色菌落扁平散在或融合成片状分布。

图6 治疗前后皮肤对比图

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