上海地区儿童肾功能生化项目参考区间的建立

doi:10.3969/j.issn.1673-8640.2018.10.003

摘要/Abstract

摘要：

目的分析上海地区3~17岁健康儿童肾功能生化项目[尿素、肌酐（Cr）、尿酸（UA）、总蛋白（TP）、白蛋白（Alb）],建立儿童肾功能生化项目的参考区间。方法选取上海地区3~17岁健康儿童1 038名,其中男543名、女495名。按年龄分为3组：3~6岁组（345名）、7~12岁组（434名）、13~17岁组（259名）。采用日立7180全自动生化分析仪检测血清尿素、Cr、UA、TP、Alb,以x±1.96s方式建立参考区间。结果除血清尿素水平外,不同年龄组血清Cr、UA、TP、Alb水平差异均有统计学意义（P<0.05）,且随年龄的增长呈明显上升趋势。7~12岁组和13~17岁组男童与女童之间血清UA、Cr水平差异均有统计学意义（P<0.05）。将年龄、性别因素合并分析后建立参考区间。尿素：3~17岁为3.36~5.41 mmol/L;Cr：3~6岁为24.47~38.07 μmol/L,7~12岁男童为33.45~49.27 μmol/L、女童为33.09~46.05 μmol/L,13~17岁男童为46.00~70.00 μmol/L、女童为42.67~60.63 μmol/L;UA：3~6岁为210.00~312.42 μmol/L,7~12岁男童为216.70~364.58 μmol/L、女童为217.27~336.53 μmol/L,13~17岁男童为287.93~474.13 μmol/L、女童为260.39~340.11 μmol/L;TP：3~6岁为66.23~74.75 g/L,7~12岁为69.12~77.64 g/L,13~17岁为70.08~78.24 g/L;Alb：3~6岁为43.62~48.14 g/L,7~12岁为44.62~48.86 g/L,13~17岁为45.28~50.28 g/L。结论初步建立了上海地区3~17岁健康儿童肾功能生化项目的参考区间。

关键词: 尿素, 肌酐, 尿酸, 总蛋白, 白蛋白, 参考区间

Abstract:

Objective To analyze the biochemical determination items [urea,creatinine（Cr）,uric acid（UA）,total protein（TP） and albumin（Alb）] for kidney function of 3-17-year-old healthy children in Shanghai,and to establish the reference ranges. Methods A total of 1 038 healthy children aged from 3 to 17 years in Shanghai,including 543 boys and 495 girls,were enrolled. The subjects were classified into 3 groups,including 3-6-year-old group（345 cases）,7-12-year-old group（434 cases） and 13-17-year-old group（259 cases）. Serum urea,Cr,UA,TP and Alb were determined by Hitachi 7180 automatic biochemical analyzer,and the reference ranges were established by x±1.96s. Results Except serum urea,there was statistical significance for serum Cr,UA,TP and Alb in different age groups（P<0.05）,and there was increasing trend with age. There was statistical significance for serum UA and Cr between 7-12-year-old group and 13-17-year-old group（P<0.05）. The reference ranges were established after the analysis of age and sex factors. The reference range of urea was 3.36-5.41 mmol/L （3-17-year-old）. The reference ranges of Cr were 24.47-38.07 μmol/L（3-6-year-old）,33.45-49.27 μmol/L（7-12-year-old boys）,33.09-46.05 μmol/L（7-12-year-old girls）,46.00-70.00 μmol/L（13-17-year-old boys） and 42.67-60.63 μmol/L（13-17-year-old girls）. The reference ranges of UA were 210.00-312.42 μmol/L（3-6-year-old）,216.70-364.58 μmol/L（7-12-year-old boys）,217.27-336.53 μmol/L（7-12-year-old girls）,287.93-474.13 μmol/L（13-17-year-old boys） and 260.39-340.11 μmol/L（13-17-year-old girls）. The reference ranges of TP were 66.23-74.75 g/L（3-6-year-old）,69.12-77.64 g/L（7-12-year-old） and 70.08-78.24 g/L（13-17-year-old）. The reference ranges of Alb were 43.62-48.14 g/L（3-6-year-old）,44.62-48.86 g/L（7-12-year-old） and 45.28-50.28 g/L（13-17-year-old）. Conclusions The reference ranges of biochemical determination items for 3-17-year-old healthy children's kidney function in Shanghai have been preliminarily established.

Key words: Urea, Creatinine, Uric acid, Total protein, Albumin, Reference range

中图分类号:

R446.1

陈时维, 叶志成, 付盼, 李巍, 杨丹, 徐锦. 上海地区儿童肾功能生化项目参考区间的建立[J]. 检验医学, 2018, 33(10): 884-887.

CHEN Shiwei, YE Zhicheng, FU Pan, LI Wei, YANG Dan, XU Jin. Reference ranges of biochemical determination items for children's kidney function in Shanghai[J]. Laboratory Medicine, 2018, 33(10): 884-887.

图/表 5

参考文献 7

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组别	例数	尿素（mmol/L）	Cr（μmol/L）	UA（μmol/L）	TP（g/L）	Alb（g/L）
3~6岁组	345	4.33±1.01	31.77±6.30^*#	261.21±51.21^*#	70.49±4.26^*#	45.88±2.26^*#
7~12岁组	434	4.44±0.95	40.67±7.44^#	285.36±69.04^#	73.38±4.26^#	46.74±2.12^#
13~17岁组	259	4.31±0.83	54.80±11.03	340.33±81.97	74.16±4.08	47.78±2.50
P值		0.203	0.000	0.000	0.000	0.000

组别	例数	尿素（mmol/L）	Cr（μmol/L）	UA（μmol/L）	TP（g/L）	Alb（g/L）
3~6岁组	345	4.33±1.01	31.77±6.30^*#	261.21±51.21^*#	70.49±4.26^*#	45.88±2.26^*#
7~12岁组	434	4.44±0.95	40.67±7.44^#	285.36±69.04^#	73.38±4.26^#	46.74±2.12^#
13~17岁组	259	4.31±0.83	54.80±11.03	340.33±81.97	74.16±4.08	47.78±2.50
P值		0.203	0.000	0.000	0.000	0.000

组别	例数	尿素（mmol/L）	Cr（μmol/L）	UA（μmol/L）	TP（g/L）	Alb（g/L）
男性组	147	4.38±1.08	31.98±6.78	265.39±52.65	70.22±4.27	45.66±2.28
女性组	198	4.27±1.00	31.61±5.98	258.11±50.03	70.69±4.25	46.04±2.18
P值		0.305	0.597	0.192	0.311	0.127

组别	例数	尿素（mmol/L）	Cr（μmol/L）	UA（μmol/L）	TP（g/L）	Alb（g/L）
男性组	147	4.38±1.08	31.98±6.78	265.39±52.65	70.22±4.27	45.66±2.28
女性组	198	4.27±1.00	31.61±5.98	258.11±50.03	70.69±4.25	46.04±2.18
P值		0.305	0.597	0.192	0.311	0.127

组别	例数	尿素（mmol/L）	Cr（μmol/L）	UA（μmol/L）	TP（g/L）	Alb（g/L）
男性组	267	4.38±1.05	41.36±7.91	290.64±73.94	73.16±4.25	46.66±2.12
女性组	167	4.43±0.81	39.57±6.48	276.90±59.63	73.74±4.24	46.86±2.12
P值		0.546	0.010	0.034	0.168	0.350