检验医学 ›› 2014, Vol. 29 ›› Issue (7): 768-773.DOI: 10.3969/j.issn.1673-8640.2014.07.018

• 综述与讲座 • 上一篇    下一篇

EGFR/PI3K/Akt细胞信号传导通路与肿瘤

孙栋勋1综述,蔡志毅2审校   

  1. 1.温州医科大学第一临床医学院,浙江 温州 325000;
    2.台州学院医学院附属市立医院耳鼻咽喉-头颈外科,浙江 台州 318000
  • 收稿日期:2013-09-28 出版日期:2014-07-30 发布日期:2014-07-21
  • 通讯作者: 蔡志毅,联系电话:0576-88858023。
  • 作者简介:孙栋勋,男,1987年生,硕士,主要从事鼻咽癌的诊断和治疗工作。
  • 基金资助:

    浙江省医药卫生科技项目(2013KYB293)

EGFR/PI3K/Akt signaling pathway with tumor

SUN Dongxun1,CAI Zhiyi2.   

  1. 1.The First Clinical Medical Institute, Wenzhou Medical College, Zhejiang Wenzhou 325000, China;
    2.Department of Otolaryngology, Municipal Hospital Affiliated to Taizhou University School of Medicine, Zhejiang Taizhou 318000, China
  • Received:2013-09-28 Online:2014-07-30 Published:2014-07-21

摘要:

表皮生长因子受体(EGFR/磷脂酰肌醇3-激酶(PI3K/蛋白激酶BPKB,也称Akt)信号通路是生物体内一条非常重要的生存信号通路。EGFR通过二聚化后刺激Ras蛋白,导致磷酸化级联反应的发生来激活PI3K/Akt信号通路,从而引起肿瘤的发生发展。本文从EGFR/PI3K/Akt信号传导通路对肿瘤的调节机制等多个方面综述了EGFR/PI3K/Akt信号通路与肿瘤的关系。

关键词: 表皮生长因子受体, 磷脂酰肌醇3-激酶, 蛋白激酶B, 肿瘤

Abstract:

Epidermal growth factor receptorEGFR/phosphatidylinositol-3-kinasePI3K/protein kinase BPKBor Akt signaling pathway is a very important survival signaling pathway. EGFR dimerization pattern can stimulate Ras protein which leads to a cascade of phosphorylation and activation of PI3K/Akt signaling pathway and then leads to the occurence of tumors.This review summarizes the relationship between EGFR/PI3K/Akt signaling pathway and tumor by analyzing the function of EGFR/PI3K/Akt signaling pathway.

Key words: Epidermal growth factor receptor, Phosphatidylinositol-3-kinase, Protein kinase B, Tumor

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